Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Modeling Heterogeneity in Health Risk Behaviors With a Dynamic Mixture Model Informed by Textual Occupational Data. [PDF]
Stat MedSchiavon L +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Unobserved Heterogeneity in the Binary Logit Model with Cross-Sectional Data and Short Panels: A Finite Mixture Approach [PDF]
This paper proposes a new approach to dealing with unobserved heterogeneity in applied research using the binary logit model with cross-sectional data and short panels.
Anders Holm +2 more
core
Identification of Fiber and Asphalt Mastic Interface Failure Modes Based on the Improved Growth Curve Mixture Model. [PDF]
Materials (Basel)Xu X, Zhou T, Ge W, Shan L.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A Mixture Model of Consumers' Intended Purchase Decisions for Genetically Modified Foods [PDF]
A finite probability mixture model is used to analyze the existence of multiple market segments for a pre-market good. The approach has at least two principal benefits.
Kristine M. Grimsrud +2 more
core
Circular mixture model-based characterization of time-of-day seizure patterns during presurgical monitoring. [PDF]
Sci RepCosta G, Dümpelmann M, Teixeira C.
europepmc +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Wild Boar and Red Deer as Key Players in Coxiella Burnetii Circulation in the Wildlife-Livestock-Human Interface: Serological Analysis Using a Gaussian Mixture Model. [PDF]
Animals (Basel)Barros L +7 more
europepmc +1 more source