Results 31 to 40 of about 541 (73)

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, Volume 64, Issue 27, July 1, 2025.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Regional disparities in Japanese children's mental health profession shortage areas

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.
Map by prefecture showing the lack of child psychiatric resources. Abstract Aim This study aims to investigate regional disparities in the distribution of child and adolescent mental health professionals in Japan. It focuses on identifying areas where access to specialists is limited and proposes potential solutions to address these inequalities ...
Masahide Usami, Yoshinori Sasaki, Mayuna Ichikawa, Miki Matsudo, Ayaka Hashimoto, Mutsumi Ohashi, Yui Higashino, Yusuke Kono, Haruna Matsudo, Yuki Nomura, Minjae Ma, Yuuki Sakoh, Maiko Odaka, Kotoe Itagaki, Keita Yamamoto Mhsw, Momoka Takahashi Mhsw, Yuta Yoshimura, Saori Inoue, Masahiro Ishida, Kumi Inazaki, Yuki Hakoshima, Yuki Mizumoto   +21 more
wiley   +1 more source

Comparison of Molnupiravir Exposure‐Response Relationships for Virology Response and Mechanism of Action Biomarkers With Clinical Outcomes in Treatment of COVID‐19

Clinical and Translational Science, Volume 18, Issue 4, April 2025.
ABSTRACT Molnupiravir, an orally administered drug for the treatment of mild‐to‐moderate COVID‐19, is a prodrug of the ribonucleoside β‐D‐N4‐hydroxycytidine (NHC). NHC incorporation in the SARS‐CoV‐2 RNA strand causes an accumulation of deleterious errors in the genome, resulting in reduced viral infectivity and replication.
Akshita Chawla, Ruthie Birger, Brian M. Maas, Youfang Cao, Hong Wan, Julie Strizki, Arthur Fridman, Amanda Paschke, Carisa de Anda, Wei Gao, Matthew L. Rizk, Wendy Painter, Wayne Holman, Susanne Sardella, George Painter, Julie A. Stone   +15 more
wiley   +1 more source

Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage

Physiological Reports, Volume 13, Issue 1, January 2025.
Abstract While autonomic dysregulation and repolarization abnormalities are observed in subarachnoid hemorrhage (SAH), their relationship remains unclear. We aimed to measure skin sympathetic nerve activity (SKNA), a novel method to estimate stellate ganglion nerve activity, and investigate its association with electrocardiogram (ECG) alterations after
Yoichiro Nakagawa, Takashi Kusayama, Sho Tamai, Yuta Nagamori, Kazutaka Takeuchi, Shuhei Iwaisako, Taishi Tsutsui, Tomoya Kamide, Kouichi Misaki, Soichiro Usui, Kenji Sakata, Mitsutoshi Nakada, Masayuki Takamura   +12 more
wiley   +1 more source

Assessment of pharmacokinetics and tolerability following single‐dose administration of molnupiravir in participants with hepatic or renal impairment

Clinical and Translational Science, Volume 17, Issue 12, December 2024.
Abstract Individuals with chronic liver or kidney disease are at increased risk of severe COVID‐19. Molnupiravir is an orally administered antiviral authorized for the treatment of mild‐to‐moderate COVID‐19 in adults at risk of progression to severe disease.
Kelly E. Duncan, Russ P. Carstens, Kristin L. Butterfield, Yoon Jin, Laura R. Inbody, Andrea K. Schaeffer, Catherine Z. Matthews, Tian Zhao, Shruti Patel, Brian M. Maas, Mickie H. Cheng, S. Aubrey Stoch, Walter Kraft, Nelia Sanchez‐Crespo, Juan Rondon, Kimberly Cruz, Julio C. Vijil   +16 more
wiley   +1 more source

Molnupiravir increases SARS‐CoV‐2 genome diversity and complexity: A case‐control cohort study

Journal of Medical Virology, Volume 96, Issue 5, May 2024.
Abstract Molnupiravir, an oral direct‐acting antiviral effective in vitro against SARS‐CoV‐2, has been largely employed during the COVID‐19 pandemic, since December 2021. After marketing and widespread usage, a progressive increase in SARS‐CoV‐2 lineages characterized by a higher transition/transversion ratio, a characteristic signature of molnupiravir
Cesare Ernesto Maria Gruber, Fabio Giovanni Tucci, Emanuela Giombini, Valentina Mazzotta, Pietro Giorgio Spezia, Martina Rueca, Ilaria Mastrorosa, Lavinia Fabeni, Giulia Berno, Ornella Butera, Silvia Rosati, Eliana Specchiarello, Fabrizio Carletti, Daniele Focosi, Emanuele Nicastri, Enrico Girardi, Andrea Antinori, Fabrizio Maggi   +17 more
wiley   +1 more source

IGF2BP2 and IGFBP3 Genotypes, Haplotypes, and Genetic Models Studies in Polycystic Ovary Syndrome

Journal of Clinical Laboratory Analysis, Volume 38, Issue 5, March 2024.
Analysis of the association between IGF2BP2 and IGFBP3 polymorphisms and the risk of polycystic ovary syndrome (PCOS) was carried out on a total of 300 subjects using both ARMS‐PCR and PCR‐RFLP methods. Visualization of gel electrophoresis patterns showed a positive association between rs1470579 and PCOS and a negative association between rs2854744 and
Fatemeh Govahi Kakhki, Saman Sargazi, Farzaneh Montazerifar, Mahdi Majidpour, Atena Karajibani, Mansour Karajibani, Marzieh Ghasemi   +6 more
wiley   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

EHA2024 Hybrid Congress

HemaSphere, Volume 8, Issue S1, June 2024.
wiley   +1 more source

Synthesis and biological evaluation of new β-D-N⁴-hydroxycytidine analogs against SARS-CoV-2, influenza viruses and DENV-2. [PDF]

Bioorg Med Chem Lett, 2023
An YJ, Choi SM, Choi ER, Nam YE, Seo EW, Ahn SB, Jang Y, Kim M, Cho JH.   +8 more
europepmc   +1 more source