Results 21 to 30 of about 541 (73)

A concise route to MK-4482 (EIDD-2801) from cytidine

Chemical Communications, 2020
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine.
N. Vasudevan, Grace P. Ahlqvist, Catherine P. McGeough, Dinesh J. Paymode, Flavio S. P. Cardoso, Tobias Lucas, Jule-Phillip Dietz, Till Opatz, Timothy F. Jamison, Frank B. Gupton, David R. Snead   +10 more
openaire   +5 more sources

Effectiveness of Antiviral Therapy in Highly-Transmissible Variants of SARS-CoV-2: A Modeling and Simulation Study

Frontiers in Pharmacology, 2022
As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection.
Verena Schöning, Charlotte Kern, Charlotte Kern, Carlos Chaccour, Carlos Chaccour, Carlos Chaccour, Felix Hammann   +6 more
doaj   +1 more source

Molnupiravir: A new candidate for COVID‐19 treatment

Pharmacology Research & Perspectives, 2022
The novel coronavirus disease 2019 (COVID‐19) emerged in late December 2019 in china and has rapidly spread to many countries around the world. The effective pharmacotherapy can reduce the mortality of COVID‐19.
Fariba Pourkarim, Samira Pourtaghi‐Anvarian, Haleh Rezaee   +2 more
doaj   +1 more source

Assessment of pharmacokinetics, safety, and tolerability following twice‐daily administration of molnupiravir for 10 days in healthy participants

Clinical and Translational Science, Volume 16, Issue 10, Page 1947-1956, October 2023., 2023
Abstract Molnupiravir is an orally administered, small‐molecule ribonucleoside prodrug of β‐D‐N4‐hydroxycytidine (NHC) that has demonstrated potent, broad‐spectrum preclinical activity against RNA viruses and has a high barrier to the development of resistance.
Marian Iwamoto, Kelly E. Duncan, Prachi K. Wickremasingha, Tian Zhao, Maria V. Liberti, Lieselotte Lemoine, Tatjana Decaesteker, Sylvie Rottey, Brian M. Maas, Gillian Gillespie, S. Aubrey Stoch   +10 more
wiley   +1 more source

Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2

MedComm, Volume 4, Issue 3, June 2023., 2023
In this review, authors provide a comprehensive overview of various identified pathogenic targets and pathways, as well as corresponding repurposed approved/clinical drugs and their potential against COVID‐19. Moreover, authors summarizenumerous potential pathogenic targets associated with viral life cycle and virus–host cell communication, repurposed ...
Yiying Xue, Husheng Mei, Yisa Chen, James D. Griffin, Qingsong Liu, Ellen Weisberg, Jing Yang   +6 more
wiley   +1 more source

Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

American Journal of Transplantation, Volume 22, Issue 12, Page 3031-3046, December 2022., 2022
Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi‐center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008–31.12.2019) were included.
Truong‐Thanh Pham, Diego O. Andrey, Susanne Stampf, Sara H. Burkhard, Cédric Hirzel, Johnathan Tschopp, Kathrin Ullrich, Carol Strahm, Peter W. Schreiber, Noémie Boillat‐Blanco, Christian Garzoni, Nina Khanna, Oriol Manuel, Nicolas J. Mueller, Domizio Suva, Christian van Delden, Ilker Uçkay, Dionysios Neofytos, the Swiss Transplant Cohort Study, Patrizia Amico, Andres Axel, John‐David Aubert, Vanessa Banz, Sonja Beckmann, Guido Beldi, Christoph Berger, Ekaterine Berishvili, Annalisa Berzigotti, Isabelle Binet, Pierre‐Yves Bochud, Sanda Branca, Heiner Bucher, Emmanuelle Catana, Anne Cairoli, Yves Chalandon, Sabina De Geest, Olivier De Rougemont, Sophie De Seigneux, Michael Dickenmann, Joëlle Lynn Dreifuss, Michel Duchosal, Thomas Fehr, Sylvie Ferrari‐Lacraz, Déla Golshayan, Nicolas Goossens, Jörg Halter, Dominik Heim, Christoph Hess, Sven Hillinger, Hans H. Hirsch, Patricia Hirt, Günther Hofbauer, Uyen Huynh‐Do, Franz Immer, Michael Koller, Mirjam Laager, Bettina Laesser, Frédéric Lamoth, Roger Lehmann, Alexander Leichtle, Hans‐Peter Marti, Michele Martinelli, Valérie McLin, Katell Mellac, Aurélia Merçay, Karin Mettler, Antonia Müller, Ulrike Müller‐Arndt, Beat Müllhaupt, Mirjam Nägeli, Graziano Oldani, Manuel Pascual, Jakob Passweg, Rosemarie Pazeller, Klara Posfay‐Barbe, Juliane Rick, Anne Rosselet, Simona Rossi, Silvia Rothlin, Frank Ruschitzka, Thomas Schachtner, Urs Schanz, Stefan Schaub, Alexandra Scherrer, Aurelia Schnyder, Macé Schuurmans, Simon Schwab, Thierry Sengstag, Federico Simonetta, Jürg Steiger, Guido Stirnimann, Ueli Stürzinger, Jean‐Pierre Venetz, Jean Villard, Julien Vionnet, Madeleine Wick, Markus Wilhelm, Patrick Yerly   +97 more
wiley   +1 more source

Molnupiravir for the treatment of COVID-19 outpatients: An updated meta-analysis

Journal of Microbiology, Immunology and Infection
Background: The majority of available data on molnupiravir come from an unvaccinated COVID-19 population. Therefore, we conducted this meta-analysis to integrate evidence from recent randomized controlled trials (RCTs) as well as observational studies ...
Huzaifa Ahmad Cheema, Saleha Abdul Rab, Momina Butt, Uzair Jafar, Abia Shahid, Aqeeb Ur Rehman, Ka Yiu Lee, Syeda Sahra, Ranjit Sah   +8 more
doaj   +1 more source

Metabolic Alterations Associated With Diet and Hypertension in Rats

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Unhealthy diet and hypertension constitute major risk factors for the development of cardiometabolic diseases. However, the direct effects of dietary components and high blood pressure on metabolic profiles remain poorly understood. We evaluated concentrations of amino acids and nutrients in the plasma and tissues of animal models subjected to high‐fat
Kristina Smoradkova, Mateusz Szudzik, Klaudia Maksymiuk, Emilia Samborowska, Adrian Drapala, Marcin Ufnal, Lenka Tomasova, Suraiya Saleem   +7 more
wiley   +1 more source

Biodiversity under pressure: In search of sustainable planning strategies

People and Nature, Volume 7, Issue 10, Page 2451-2464, October 2025.
Abstract Land use change in and around urban areas is a major driver of biodiversity loss. Such processes have mostly been studied in large cities, and to a much lesser extent in towns and villages. There is an urgent need for nature positive planning principles that recognize the planetary boundaries and are anchored among decision‐makers.
Kyrre Groven, Inger Auestad, Karen Richardsen Moberg, Liv Norunn Hamre   +3 more
wiley   +1 more source

Update: Enzymatische Synthese für industrielle Anwendungen

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Die Biokatalyse hat sich zu einer nachhaltigen und wettbewerbsfähigen Alternative zur herkömmlichen chemischen Synthese entwickelt und ermöglicht die enzymbasierte Herstellung nicht nur von chemischen Grundstoffen, sondern auch von (nicht natürlichen) Aminosäuren, (seltenen) Zuckern und synthetischen Nukleotiden.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source