Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine [PDF]
ACS Omega, 2021 Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for treatment of COVID-19. Herein we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed by transamination to yield the final drug product.
Grace P. Ahlqvist +8 more
doaj +8 more sources
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model [PDF]
Nature Communications, 2021 While vaccines protecting against SARS-CoV-2 infection are approved, currently, there are no drugs suitable for high-risk exposure use against SARS-CoV-2. Here, Rosenke et al.
Kyle Rosenke +16 more
doaj +4 more sources
Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2 [PDF]
Trials, 2021 A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral agent with potent activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the ...
Wendy Holman +6 more
doaj +5 more sources
Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model [PDF]
, 2022 ABSTRACT The recent emergence of the SARS-CoV-2 Omicron variant of concern (VOC) containing a heavily mutated spike protein capable of escaping preexisting immunity, identifies a continued need for interventional measures. Molnupiravir (MK-4482), an orally administered nucleoside analog, has demonstrated efficacy against earlier SARS ...
Rosenke, Kyle +10 more
openaire +3 more sources
Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets [PDF]
Nature Microbiology, 2020 The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health1. Widespread community transmission has triggered stringent distancing measures with severe socio-economic consequences. Gaining control of the pandemic will depend on the interruption of transmission chains until vaccine-induced or naturally acquired ...
Cox, Robert M. +2 more
openaire +3 more sources
Therapeutic MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets [PDF]
, 2020 Abstract The COVID-19 pandemic is having a catastrophic impact on human health. Widespread community transmission has triggered stringent distancing measures with severe socioeconomic consequences. Gaining control of the pandemic will depend on interruption of transmission chains until protective herd immunity arises.
Cox, Robert M. +2 more
openaire +3 more sources
Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques [PDF]
JCI Insight, 2023 The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions.
Kyle Rosenke +13 more
doaj +2 more sources
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model [PDF]
, 2020 Abstract The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial benefit in controlling the COVID-19 pandemic.
Kyle Rosenke +14 more
openaire +3 more sources
Population pharmacokinetics of molnupiravir in adults with COVID‐19: Lack of clinically important exposure variation across individuals [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2023 Effective antiviral treatments for coronavirus disease 2019 (COVID‐19) are needed to reduce the morbidity and mortality associated with severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection, particularly in patients with risk factors for
Sébastien Bihorel +20 more
doaj +2 more sources
Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model [PDF]
JCI Insight, 2022 The recent emergence of the SARS-CoV-2 Omicron variant of concern (VOC), which contains a heavily mutated spike protein capable of escaping preexisting immunity, identifies a continued need for interventional measures.
Kyle Rosenke +10 more
doaj +2 more sources