Results 131 to 140 of about 46,287 (264)

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source

Methylation-sensitive high-resolution melting technology is a simple and sensitive method to detect germline epimutation of the MLH1 gene promoter

Clinical Epigenetics
Background Lynch syndrome is an autosomal dominant cancer predisposition syndrome classically caused by germline mutations of the mismatch repair genes MLH1, MSH2, MSH6 and PMS2.
Hélène Delhomelle, Olfa Trabelsi-Grati, Marie-Charlotte Villy, Sabrina Ibadioune, Frederic Maraone, Mathieu Séné, Bruno Buecher, Emmanuelle Mouret-Fourme, Marion Gauthier-Villars, Faustine Johannes, Lisa Golmard, Anne Vincent-Salomon, Eric Pasmant, Julie Leclerc, Michel Bahuau, Ivan Bièche, Chrystelle Colas   +16 more
doaj   +1 more source

Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.

PLoS ONE, 2019
IntroductionColorectal cancers (CRCs) deficient in the DNA mismatch repair protein MutL homolog 1 (MLH1) display distinct clinicopathological features and require a different therapeutic approach compared to CRCs with MLH1 proficiency.
Anne Ackermann, Christopher Schrecker, Dimitra Bon, Nicolaus Friedrichs, Katrin Bankov, Peter Wild, Guido Plotz, Stefan Zeuzem, Eva Herrmann, Martin-Leo Hansmann, Angela Brieger   +10 more
doaj   +1 more source

Correlation of MLH1 and MSH2 levels with clinicopathologic characteristics in colorectal cancer. [PDF]

, 2023
Ling T. Guo, Zhaohui Yu, Qin Li, Xiaohu Liang, Lindong Yang   +4 more
openalex  

CHARACTERISTICS OF INDIVIDUALS UNDERGOING PANEL GENETIC TESTING FOR PRIMARY BRAIN TUMORS [PDF]

, 2018
Background. Currently, there are no genetic testing guidelines for patients with a primary brain tumor (PBT). This population is largely understudied in terms of the family history, tumor grade, pathology, and their relation to genetic contribution.
Azam, Sarah
core   +1 more source

Remote delivery of cancer genetic testing in veterans with metastatic prostate cancer: A Million Veteran Program pilot study

Cancer, Volume 132, Issue 3, 1 February 2026.
Abstract Background Germline pathogenic variants can inform targeted therapy for metastatic prostate cancer (mPC), and improve cancer early detection and risk reduction for family members. Guidelines recommend germline genetic testing be offered to all men with mPC, yet uptake of testing is only 10%–12%. Methods This prospective study enrolled veterans
Bruce Montgomery, Julie A. Lynch, Jessica Brown, Kara N. Maxwell, Craig C. Teerlink, Nismeta Kabilovic, Katie Stoll, Julie Simon, Maria Kogan, Sajida Hassan, Stacey B. Whitbourne, Sumitra Muralidhar, Martin W. Schoen, Rachel Ramoni, J. Michael Gaziano, Alexandra O. Sokolova, Heather H. Cheng, Ruth Etzioni, Colin C. Pritchard   +18 more
wiley   +1 more source

Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1

Cell Reports, 2014
Silencing of MLH1 is frequently seen in sporadic colorectal cancers. We show here that hypoxia causes decreased histone H3 lysine 4 (H3K4) methylation at the MLH1 promoter via the action of the H3K4 demethylases LSD1 and PLU-1 and promotes durable long ...
Yuhong Lu, Narendra Wajapeyee, Mitchell S. Turker, Peter M. Glazer   +3 more
doaj   +1 more source

Cytological Features of Pancreatic Medullary Carcinoma Diagnosed by Endoscopic Ultrasound‐Guided Fine Needle Aspiration

Diagnostic Cytopathology, Volume 54, Issue 2, Page E54-E58, February 2026.
ABSTRACT Pancreatic medullary carcinoma is an extremely rare tumor classified as a histological subtype of pancreatic ductal adenocarcinoma. We report a case of a pancreatic medullary carcinoma and describe its cytological features. A 75‐year‐old woman presented with lower back pain, epigastric discomfort, and a tumor‐like lesion in the pancreatic body.
Urara Okawa, Keishi Mizuguchi, Miyu Okuda, Tatsuya Mori, Hiroko Ikeda   +4 more
wiley   +1 more source

BRAF testing in a South African cohort of MLH1 deficient endometrial carcinomas: lessons learnt [PDF]

, 2021
Reubina Wadee, Wayne Grayson
openalex   +1 more source

GENETIC COUNSELOR UTILIZATION AND INTERPRETATION OF SOMATIC TUMOR TESTING IN EVALUATION FOR LYNCH SYNDROME [PDF]

, 2019
Lynch syndrome (LS) is a hereditary cancer predisposition syndrome characterized by increased risk for colorectal and uterine cancers. Individuals with pathogenic variants in the mismatch repair (MMR) genes (MLH1, MSH2/EPCAM, MSH6, PMS2) are diagnosed ...
Williams, Danielle
core   +1 more source