Results 121 to 130 of about 33,127 (201)

A Novel BRCA1 Pathogenic Variant in Tunisian Patient With High Grade Ovarian Cancer: Favorable Therapeutic Response to Olaparib

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Ovarian cancer is one of the leading causes of death from gynecological cancer worldwide. Genetic mutations in genes involved in key cellular functions such as BRCA1/2 play a central role in tumorigenesis and have major implications for targeted therapeutic strategies, especially the use of poly (ADP‐ribose) polymerase (PARP ...
Nihel Ammous‐Boukhris, Rania Abdelmaksoud‐Dammak, Ameni Feki, Souhir Khemiri, Slim Charfi, Tahia Sallemi‐Boudawara, Jamel Daoud, Afef Khanfir, Raja Mokdad Gargouri   +8 more
wiley   +1 more source

A POLE P286R‐Mutated Hepatoid Adenocarcinoma of the Lung Showing Substantial Response to Immune Checkpoint Inhibition

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Hepatoid adenocarcinoma of the lung (HAL) is a rare form of lung cancer with histological and morphological properties of hepatocellular carcinoma, characterized by an aggressive course of the disease and unfavorable prognosis. Given the rarity of the pathology and the lack of unambiguous therapeutic protocols, descriptions of ...
Aleksey Chernev, Alina Kaurtseva, Ruslan Abasov, Rafael Enikeev, Nina Gegelia, Gulnara Abdrakova, Natalia Usman, Alexander Druy, Grigory Raskin   +8 more
wiley   +1 more source

Microsatellite Instability‐High Somatic‐Type Malignancy Arising From a Primary Retroperitoneal Germ Cell Tumor: A Case Report

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Immune checkpoint inhibitors have shown only limited clinical efficacy in germ cell tumors (GCTs), underscoring the need for predictive biomarkers such as microsatellite instability‐high (MSI‐high). We report a rare case of mixed‐type GCTs treated with chemotherapy, in which the somatic‐type malignancy (STM) component was found to
Gaku Hayashi, Tomokazu Kimura, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Kenji Zennami, Shohei Ishida, Akira Satou, Shusuke Akamatsu   +8 more
wiley   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

The relationship between MLH1 methylation and MSI.

, 2015
a) Venn diagram showing the overlap of MLH1 5' methylation and 3' methylation status. The overlapping relationship between MLH1 5'—and 3' methylation status was analyzed.
Ajay Goel (130080), Naosuke Yokomichi (453017), Tomokazu Fuji (762719), Kunitoshi Shigeyasu (762718), Toshiyoshi Fujiwara (157767), Keisuke Kimura (762720), Takeshi Nagasaka (8474), Yuzo Umeda (762721), Yoshiko Mori (459176), Shunsuke Kagawa (157766), Takashi Kawai (754711)   +10 more
core   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Licensing MLH1 sites for crossover during meiosis

, 2014
During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related ...
Phillips, Dylan, Martín Ramírez, Azahara Carmen, Moore, Graham, Shaw, Peter, Reader, Steve   +4 more
core   +1 more source

Knowledge gaps in tubular gut tumours: a critical appraisal of the 6th edition of the World Health Organization classification of tumours

The Journal of Pathology, Volume 270, Issue 1, Page 4-22, September 2026.
Abstract Gastrointestinal cancer is a global health problem. In the new 6th edition of the World Health Organization Classification of Tumours (WCT) of the Digestive System, updated evidence and guidance is provided for the aetiology, pathogenesis, diagnosis, classification, grading, staging and prognosis of these tumours.
Iris D Nagtegaal, Elizabeth A Montgomery, Alexandros D Polydorides, Anthony J Gill, Motohiro Kojima, Mark J Arends   +5 more
wiley   +1 more source

Variants in ZZS Complex‐Associated Genes TEX11 and M1AP Are Responsible for Male Infertility and Nonobstructive Azoospermia

Andrology, Volume 14, Issue 6, Page 1847-1858, September 2026.
ABSTRACT Background Nonobstructive azoospermia (NOA) is the most severe form of male infertility, with genetic factors contributing to approximately 30% of cases. However, only a small fraction of all NOA cases can be explained by the current genetic findings.
Ao Ma, Hongyi Wang, Shengwei Ke, Ziqi Yu, Xun Wang, Zhiran Li, Yuhang Li, Lv Yao, Fuxing Zhang, Feifei Kong, Lingying Jiang, Xiaozhi Zhao, Beibei Zhang   +12 more
wiley   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for Genetics

Clinical Genetics, Volume 110, Issue 3, Page 389-401, September 2026.
The WHO Classification of Tumours underpins the diagnosis of neoplastic conditions. The new WHO classification of genetic tumour syndromes (GTS) provides international standards for their diagnosis. This diagram highlights the chromosomal distribution of the genes involved in the GTS covered in this classification.
Ian A. Cree, Mark J. Arends, Joseph D. Khoury, Erika R. E. Denton, Anthony J. Gill, Alexander J. Lazar, Ian M. Frayling, Stefan M. Pfister, Mark A. Rubin, Katia R. M. Leite, Raymond Dalgleish, Elspeth A. Bruford, Sharon E. Plon, Ada Hamosh, Michael Francis Walsh, Gabrielle Goldman‐Lévy, Harshima Wijesinghe, William D. Foulkes, Dilani Lokuhetty   +18 more
wiley   +1 more source