Results 131 to 140 of about 33,127 (201)

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, Volume 89, Issue 3, Page 442-455, September 2026.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Causes of DNA mismatch repair deficiency in sebaceous skin lesions demonstrating loss of MLH1 protein expression: constitutional over somatic MLH1 promoter methylation

Approximately 30% of sebaceous skin lesions (or sebaceous neoplasia) demonstrate DNA mismatch repair (MMR)-deficiency. MMR-deficiency can be caused by Lynch syndrome, resulting from germline pathogenic variants in the DNA MMR genes MLH1, MSH2, MSH6 and ...
Georgeson, P, Walsh, MD, Mahmood, K, Como, J, Walker, R, Buchanan, DD, Jenkins, MA, Winship, IM, Clendenning, M, Joo, JE   +9 more
core   +1 more source

In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines—An Exploratory Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Anaesthetic agents are essential for surgical procedures, yet their potential role on tumour cell biology remains incompletely understood. Emerging evidence suggests that these compounds can act both as protumor and antitumor agents, influencing cellular processes such as proliferation, migration and cell death mechanisms.
Olga Grajdieru, Alexandru Cristian Sabo, Adrian Bogdan Tigu, Andrei Ivancuta, Cristian Silviu Moldovan, Andrada Uhl, Miruna Cristina Ungurenasu, Andrada‐Ioana Balmez, Ada Moisescu, Simina Pîrv, Madalina Nistor, Ximena‐Maria Muresan, Diana Cenariu, Ciprian Tomuleasa, Catalin Constantinescu   +14 more
wiley   +1 more source

Mismatch repair protein MLH1 controls testis development by regulating the Hippo-YAP signaling pathway. [PDF]

Nucleic Acids Res
Li X, Yang J, Li GM.
europepmc   +1 more source

The Tyrolean Founder <i>MLH1</i> Variant c.836T>G Causes Lynch Syndrome Due to a Leaky Splice Effect. [PDF]

Biomolecules
Horpaopan S, Schamschula E, Fiegl H, Dapoz H, Lutz-Nicoladoni C, Schnaiter S, Amberger A, Strasser U, Lunzer R, von der Heidt A, Csanaky K, Zschocke J, Wimmer K.   +12 more
europepmc   +1 more source

Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα. [PDF]

Nat Commun
Ghosh A, Ran X, Zhang F, Gao B, Xu Y, Phoon LY, Long M, Wang M, Ananthapadmanabhan V, Kawale A, Shah Y, Manzano-Winkler B, Ott CJ, Zou L, Lan L.   +14 more
europepmc   +1 more source

DNA methylation signatures of sporadic colorectal cancer with microsatellite instability. [PDF]

Epigenetics
Ward R, Endicott M, Mallabar-Rimmer B, Burrage J, Sherwood K, Huang Q, Ward JC, Thorn S, Woolley C, Wood SJ, Dempster E, Green HD, Tomlinson I, Webster AP.   +13 more
europepmc   +1 more source

Prognostic relevance of secondary actionable fusions in MLH1-deficient dMMR/MSI-H gastrointestinal tumors treated with pembrolizumab. [PDF]

ESMO Gastrointest Oncol
Martínez Lago N, Sánchez Ares M, Carral Maseda A, Pérez Martelo M, Covela Rúa M, Fernández Montes A, de la Cámara Gómez J, González Villarroel P, Reboredo López M, Padín Iruegas ME, Abdulkader Nallib I.   +10 more
europepmc   +1 more source

Bayesian Integration of Tumor Mutational Signatures and Somatic Features Refines Pathogenicity Assessment of Germline Mismatch Repair Variants. [PDF]

Hum Mutat
Amzaleg Y, McDonnell KJ, Idos GE, Mathai C, Gray SW, Hampel H, Craig DW.   +6 more
europepmc   +1 more source

Mild inflammation accelerates colon carcinogenesis in Mlh1- deficient mice

, 2007
Deficiencies in DNA mismatch repair (MMR) result in replication errors within key tumor suppressor genes or oncogenes, and cause hereditary nonpolyposis colorectal cancer (HNPCC).
Shimada, Yoshiya, 445051, 445050, Kohno, Hiroyuki, 445053, Nishimura, Mayumi, 445052, 445055, 445054, 445035, 柿沼 志津子, 445034, 445056, 445037, 今岡 達彦, 445036, Arai, Masami, 谷口 和樹, 西村 まゆみ, 445049, 東海林 裕, Ito, Eisaku, Wakabayashi, Keiji, 新井 正美, Kakinuma, Shizuko, 山内 一己, Koike, Morio, 杉原 健一, 445040, Tokairin, Yutaka, 445042, Sugihara, Kenichi, 445041, 445044, 445043, 445046, 445045, 445048, 島田 義也, Uetake, Hiroyuki, 445047, 445039, 445038, Yamauchi, Kazumi, Imaoka, Tatsuhiko, Taniguchi, Kazuki   +45 more
core