Results 151 to 160 of about 396,778 (337)

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Promoting Treg Polarization‐Mediated Anti‐Scar and Appendage Regeneration in Wound Healing

Advanced Science, EarlyView.
This study develops a PLGA@LA‐BMP4‐PG bilayer scaffold to address scar formation and appendage loss in skin repair. The piezoelectric PLA layer enhances cell migration via electric fields, while GelMA delivers LA promoting Tregs polarization and BMP4 inhibiting FBs differentiation.
Yiwen Yang, Mingjie Kuang, Jiacheng Shi, Ruiyan Li, Yuhan Zhang, Xinting Liu, Runtan Li, Yong Kang, Bin Yao, Shuquan Zhang, Xiaoyuan Ji   +10 more
wiley   +1 more source

Investigation on MMP-9 concentration in sera of people infected by Helicobacter pylori [PDF]

Objectives: Helicobacter Pylori (HP), as a gram negative bacterium colonizing in the gastric mucosa, induces gastrodeudenal complications varying from mild gastritis to gastric malignancies.
اتحاد, غلامحسین, امانی, مجتبی, پرستار, ندا   +2 more
core  

Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells

, 2005
Nicoletta Gagliano, Claudia Moscheni, Carlo Torri, Ivana Magnani, A Bertelli, Magda Gioia   +5 more
openalex   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

PENGELOLAAN PEMBELAJARAN SIKAP DEMOKRATIS DI SMP MUHAMMADIYAH 1 KARTASURA

Jurnal Pendidikan Ilmu Sosial, 2015
The purpose of this study were to determine: 1) Democratic values that the students developed in junior high school Muhammadiyah 1 of Kartasura students; 2) Learning strategy of democratic attitude in junior high school Muhammadiyah 1 of Kartasura; 3 ...
Nur Chayati, Eko Supriyanto, Muhammad Yahya   +2 more
doaj  

Free Fatty Acid Receptor 1 Signaling Contributes to Migration, MMP-9 Activity, and Expression of IL-8 Induced by Linoleic Acid in HaCaT Cells [PDF]

, 2020
Carolina Manosalva, Pablo Alarcón, Karina González, Jorge A. Soto, Karin Igor, F. J. García Peña, Gustavo Medina, Rafael A. Burgos, María A. Hidalgo   +8 more
openalex   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology [PDF]

, 2011
Piotr Michaluk, Marcin Wawrzyniak, Przemyslaw Alot, Marcin Szczot, Paulina Wyrembek, Katarzyna Mercik, Nikolay Medvedev, Ewa Wilczek, Mathias De Roo, Werner Zuschratter, Dominique Müller, Grzegorz M. Wilczyński, Jerzy W. Mozrzymas, Michael G. Stewart, Leszek Kaczmarek, Jakub Włodarczyk   +15 more
openalex   +1 more source

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source