Results 61 to 70 of about 9,951 (244)

The role of mNGS in the diagnosis of talaromycosis and case series

BMC Infectious Diseases
Talaromycosis is a rare fungal infection characterized by non-specific clinical features, often resulting in misdiagnosis. This study aimed to analyze four classic cases of Talaromyces marneffei infection diagnosed using metagenomic next-generation sequencing (mNGS) to improve understanding of its diagnosis and treatment.This study retrospectively ...
Jing Zhao, Hui-Ting Su, Dong Zhang, Xue-Tong Li, Min-Ya Lu, Juan Du, Jia-Yu Guo, Yi Gao, Xin-Fei Chen, Dong-Hua Wen, Shi-Yu Jia, Yao Wang, Qi-Wen Yang   +12 more
openaire   +3 more sources

Fixation Induces Mislocalization of Thin Filament Components in Caenorhabditis elegans Striated Muscle

Cytoskeleton, EarlyView.
ABSTRACT The simple nematode Caenorhabditis elegans has long served as a powerful genetic model system for studying muscle structure and function, with sarcomeres of the striated body wall muscle (BWM) that are considered largely homologous to those in vertebrates.
Michael J. Kimmich, Pu Zhang, Bob Goldstein, David Pruyne   +3 more
wiley   +1 more source

A Paired Comparison of Plasma and Bronchoalveolar Lavage Fluid for Metagenomic Next-Generation Sequencing in Critically Ill Patients with Suspected Severe Pneumonia

Infection and Drug Resistance, 2022
Ting Sun,1 Yijie Liu,2 Ying Cai,3 Tianshu Zhai,3 Yun Zhou,4 Bin Yang,5 Xiaojing Wu,3,* Qingyuan Zhan1,3,* 1Capital Medical University China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 2Graduate School of ...
Sun T, Liu Y, Cai Y, Zhai T, Zhou Y, Yang B, Wu X, Zhan Q   +7 more
doaj  

Exploring the pathogen diagnosis and prognostic factors of severe COVID-19 using metagenomic next-generation sequencing: A retrospective study [PDF]

Journal of Medical Biochemistry
Background: This study aimed to identify pathogens and factors that predict the outcome of severe COVID-19 by utilizing metagenomic next-generation sequencing (mNGS) technology.
Zeng Weizhong, Liang Yanchao, He Xiaoyuan, Chen Fangwei, Xiong Jiali, Wen Zhenhua, Tang Liang, Chen Xun, Zhang Juan   +8 more
doaj   +1 more source

Clinical features of varicella-zoster virus caused neurological diseases detected by metagenomic next-generation sequencing

Open Medicine, 2023
Clinical presentation of central nervous system (CNS) infections caused by varicella-zoster virus (VZV) is highly sophisticated, making identification challenging.
Xie Shuhua, Yang Xuying, Xia Han, Lai Jinxing, Liu Qing, Lu Zhijuan, He Dehai, Liu Xianghong   +7 more
doaj   +1 more source

Comparison of metagenomic next-generation sequencing using cell-free DNA and whole-cell DNA for the diagnoses of pulmonary infections

Frontiers in Cellular and Infection Microbiology, 2022
Although the fast-growing metagenomic next-generation sequencing (mNGS) has been used in diagnosing infectious diseases, low detection rate of mNGS in detecting pathogens with low loads limits its extensive application.
Ping He, Jing Wang, Rui Ke, Wei Zhang, Pu Ning, Dexin Zhang, Xia Yang, Hongyang Shi, Ping Fang, Zongjuan Ming, Wei Li, Jie Zhang, Xilin Dong, Yun Liu, Jiemin Zhou, Han Xia, Shuanying Yang   +16 more
doaj   +1 more source

A Processing‐Oriented Perspective on Advanced Anode Materials: From Graphite to Si‐Based Systems

EcoEnergy, EarlyView.
This review provides a processing‐oriented framework for graphite and Si‐based anodes, linking material‐specific fabrication routes with manufacturability, scalability, cost, and industrial feasibility. This transition from established graphite processing to emerging Si‐based manufacturing strategies highlights practical pathways toward next‐generation
Seh‐Yoon Lim, Jung Ho Kim, Taehyeon Son, Junyoung Mun   +3 more
wiley   +1 more source

Clinical pathogen profiles and lung microbiome features in lung infection patients and concurrent cancer: insights from metagenomics next-generation sequencing

Open Life Sciences
Pulmonary infections in immunocompromised cancer patients present significant diagnostic and therapeutic challenges. From Dec 2021 to Aug 2023, 85 patients with pulmonary infection were enrolled and categorized into a cancer group (CP, n = 20) and a non ...
Liu Dandan, Ma Yuehong, Ma Qian, Huang Huihua, Li Tianyu, Wang Jin, Zhang Jin, Cheng Xuesong, Ge Xueru, Chen Yan, Zhang Yanbei   +10 more
doaj   +1 more source

The Performance of Metagenomic Next-Generation Sequence in the Diagnosis of Suspected Opportunistic Infections in Patients with Acquired Immunodeficiency Syndrome [Corrigendum]

Infection and Drug Resistance, 2023
Liu L, Yuan M, Sun S, et al. Infect Drug Resist. 2022;15:5645–5653. The authors have advised that affiliation 1 on page 5645 is incorrect.
Liu L, Yuan M, Sun S, Wang J, Shi Y, Yu Y, Su X   +6 more
doaj  

Functional profiling of STXBP1 missense variants using a novel dual‐readout fluorometric assay

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorders (STXBP1‐RD) are among the most common genetic neurodevelopmental disorders, marked by early onset epilepsy, global developmental delay, and motor impairments. Many missense variants remain uncharacterized, limiting accurate variant interpretation and hindering development of precision therapies.
Elisa A. Waxman, Jennine M. Dawicki‐McKenna, Ian McSalley, Anna J. Prentice, Torrey A. Chisari, Sarah M. Ruggiero, Jillian L. McKee, Alex J. Felix, Giulia Pavani, Benjamin L. Prosser, Michael J. Boland, Ingo Helbig   +11 more
wiley   +1 more source