Results 61 to 70 of about 1,429,953 (284)

Deciphering Predictability Limits in Human Mobility [PDF]

Proceedings of the 27th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems, 2019
Human mobility has been studied from different perspectives. One approach addresses predictability, deriving theoretical limits on the accuracy that any prediction model can achieve in a given dataset. This approach focuses on the inherent nature and fundamental patterns of human behavior captured in the dataset, filtering out factors that depend on ...
Teixeira, Douglas, Carneiro Viana, Aline, Alvim, Mário, Almeida, Jussara   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Effect of Short-Term Conditional-Equilibrium Exercises on Balance and Functional Limitations in Aged Women With Frailty Syndrome: A Randomized Controlled Trail

Sālmand, 2022
Objectives Increasing frailty syndrome is one consequence of the aging population. Frailty syndrome can adversely affect the independent life and social activities of the elderly by threatening their balance and mobility.
Foruzan Tavan, Mahsa Yarelahi, Negin Chehrehnegar, Abdolrahim Asadollahi   +3 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Activities of Daily Living and Life-Space Mobility in Older Adults with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
Isabel Fialho Fontenele Garcia,1 Carina Tiemi Tiuganji,1 Maria do Socorro Morais Pereira Simões,2 Adriana Claudia Lunardi1,3 1Master’s and Doctoral, Programs in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP,
Garcia IFF, Tiuganji CT, Simões MSMP, Lunardi AC   +3 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Barrier coverage with sensors of limited mobility [PDF]

Proceedings of the eleventh ACM international symposium on Mobile ad hoc networking and computing, 2010
Barrier coverage is a critical issue in wireless sensor networks for various battlefield and homeland security applications. The goal is to effectively detect intruders that attempt to penetrate the region of interest. A sensor barrier is formed by a connected sensor cluster across the entire deployed region, acting as a "trip wire" to detect any ...
Anwar Saipulla, Benyuan Liu, Guoliang Xing, Xinwen Fu, Jie Wang 0002   +4 more
openaire   +1 more source

Ecosystem and Business Models of the UMOS-MobilitEU Mobility Service Platform [PDF]

, 2022
This report presents the findings of the detailed analysis of the current state of practice in the Mobility-as-a-Service (MaaS) landscape, and their reflection on the UMOS/MobilitEU MObility Service Platform business models and their viability.
Ozkan, Baris, Adali, O. Ege, Athanasopoulou, Alexia, Türetken, Oktay, Gilsing, Rick, Boer, Merijn   +5 more
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