Results 71 to 80 of about 170,458 (283)

Activities of Daily Living and Life-Space Mobility in Older Adults with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
Isabel Fialho Fontenele Garcia,1 Carina Tiemi Tiuganji,1 Maria do Socorro Morais Pereira Simões,2 Adriana Claudia Lunardi1,3 1Master’s and Doctoral, Programs in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP,
Garcia IFF, Tiuganji CT, Simões MSMP, Lunardi AC   +3 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Complex Association Between Fear of Falling and Mobility Limitation in Relation to Late-Life Falls: A SHARE-Based Analysis

, 2017
Objective: This study examines fear of falling (FOF) in relation to falls in light of mobility limitation. Method: Data on community-dwelling older Europeans, aged 65+, were drawn from two consecutive waves of the Survey of Health, Ageing and Retirement
Ayelet Dunsky, Howard Litwin, Bracha Erlich   +2 more
core   +1 more source

Prediction of Functional Movement Screen Scores in Men Firefighters by the Performance in Deep Squat Test

مجله پژوهش در علوم توانبخشی, 2018
Introduction: Functional movement screen (FMS), a seven-test battery, has been introduced to identify individuals at risk of injury. It is sometimes impossible to use the whole FMS battery, due to the limitations of time or resources.
Mustafa Ziaei, Vahid Zolaktaf
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Limited finger joint mobility in diabetes [PDF]

Archives of Disease in Childhood, 1982
Limited finger joint mobility was assessed in 112 diabetic children, in their first-degree relatives, and in 50 unrelated non-diabetic children. In 42% of the diabetic children there was limited joint mobility, but 14% of them had more severe involvement. Limited joint mobility was correlated with increasing age, early presentation, and longer duration
J E, Brice, D I, Johnston, J L, Noronha
openaire   +2 more sources

Type and intensity of activity and risk of mobility limitation: the mediating role of muscle parameters

, 2005
2,719 kcal/wk of total physical activity). The study outcome, incident mobility limitation, was defined as two consecutive, semiannual self-reports of any difficulty walking one quarter of a mile or climbing 10 steps.
Brach, J.S., Brach, Jennifer S, Newman, Anne B, Harris, T.B., Visser, M., Newman, A.B., Kritchevsky, Stephen B, Harris, Tamara B, Visser, Marjolein, Rubin, Susan M, Simonsick, E.M., Colbert, Lisa H, Simonsick, Eleanor M, Kritchevsky, S.B., Visser, Marjolein; id_orcid, Colbert, L.H., Rubin, S.M.   +16 more
core   +1 more source

Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study [PDF]

, 2017
OBJECTIVES: The current Recommended Dietary Allowance (RDA) for protein is based on short-term nitrogen balance studies in young adults and may underestimate the amount needed to optimally preserve physical function in older adults.
Katelyn Garcia, Marjolein Visser, Garcia, Katelyn, Rubin, Susan M., Janet A. Tooze, Kritchevsky, Stephen B., Susan Rubin, Tooze, Janet A., Anne B. Newman, Visser, Marjolein, Rubin, Susan, null null, Harris, Tamara B., Newman, Anne B., Tamara B. Harris, Stephen B. Kritchevsky, Denise K. Houston, Visser, Marjolein; id_orcid, Houston, Denise K.   +18 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source