Results 81 to 90 of about 165,746 (253)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cardiometabolic risk factors and multidomain functional, cognitive, and sensory impairments among tribal adults aged 45 years and above in India: evidence to inform healthy aging policy

Frontiers in Public Health
BackgroundEvidence on functional, cognitive, and sensory impairments among aging tribal populations in India is inadequate, limiting the effectiveness of ongoing public health policies and programmes aimed at healthy aging and equity.
U. Venkatesh, Margubur Rahaman, Varkey Nadakkavukaran Santhosh, Anand Mohan Dixit, Vibha Dutta   +4 more
doaj   +1 more source

Degenerative Pathology of the Ankle, Hindfoot, and Midfoot is as Limiting to Patient Mobility as Congestive Heart Failure

Foot & Ankle Orthopaedics, 2019
Category: Ankle, Ankle Arthritis, Hindfoot, Midfoot/Forefoot Introduction/Purpose: Degenerative conditions of the ankle, hindfoot, and midfoot can markedly limit mobility.
Amalie Erwood BS, Gregory Kurkis MD, Samuel David Maidman BA, Robert Cole, Shay Ariel Tenenbaum MD, Jason Tyler Bariteau MD   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Environmental settings and families' socioeconomic status influence mobility and the use of mobility devices by children with cerebral palsy Contextos ambientais e nível socioeconômico das famílias influenciam a mobilidade e a utilização de dispositivos de suporte por crianças com paralisia cerebral

Arquivos de Neuro-Psiquiatria, 2013
Functional mobility of children with cerebral palsy (CP) is influenced by personal and environmental factors, serving as barriers and/or facilitators and impacting on children's strategies and functional outcome.
Valéria C. R. Cury, Priscilla R. P. Figueiredo, Marisa C. Mancini   +2 more
doaj  

Functional, nutritional and social factors associated with mobility limitations in the elderly: a systematic review

Salud Pública de México, 2018
Objective. To systematically review the prevalence and in­cidence of mobility limitations in the elderly people and their associated factors. Materials and methods.
José Rodolfo Torres de Araújo, Rafael Rodolfo Tomaz de Lima, Ila Maria Ferreira-Bendassolli, Kenio Costa-de Lima   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Intensive Multimodal Training to Improve Gait Resistance, Mobility, Balance and Cognitive Function in Persons With Multiple Sclerosis: A Pilot Randomized Controlled Trial

Frontiers in Neurology, 2018
Introduction: Persons with multiple sclerosis (MS) have deficits in many aspects of physical and cognitive functioning that can impact on mobility and participation in daily life.
Johanna Jonsdottir, Elisa Gervasoni, Thomas Bowman, Rita Bertoni, Eleonora Tavazzi, Marco Rovaris, Davide Cattaneo   +6 more
doaj   +1 more source