Results 71 to 80 of about 609,230 (291)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Group exercises for patient with mobility limitation

نشریه پرستاری ایران, 1991
Extract: physical mobility and exercise are necessary for people health. For patient with mobility limitation this issue has more importance because these exercises help them to return to normal function more effectively.
Ghabeljoo M
doaj  

Degenerative Pathology of the Ankle, Hindfoot, and Midfoot is as Limiting to Patient Mobility as Congestive Heart Failure

Foot & Ankle Orthopaedics, 2019
Category: Ankle, Ankle Arthritis, Hindfoot, Midfoot/Forefoot Introduction/Purpose: Degenerative conditions of the ankle, hindfoot, and midfoot can markedly limit mobility.
Amalie Erwood BS, Gregory Kurkis MD, Samuel David Maidman BA, Robert Cole, Shay Ariel Tenenbaum MD, Jason Tyler Bariteau MD   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Sarcopenia With Limited Mobility: An International Consensus [PDF]

Journal of the American Medical Directors Association, 2011
A consensus conference convened by the Society of Sarcopenia, Cachexia and Wasting Disorders has concluded that "Sarcopenia, ie, reduced muscle mass, with limited mobility" should be considered an important clinical entity and that most older persons should be screened for this condition.
John E. Morley, Angela Marie Abbatecola, Josep M. Argiles, Vickie Baracos, Juergen Bauer, Shalender Bhasin, Tommy Cederholm, Andrew J. Stewart Coats, Steven R. Cummings, William J. Evans, Kenneth Fearon, Luigi Ferrucci, Roger A. Fielding, Jack M. Guralnik, Tamara B. Harris, Akio Inui, Kamyar Kalantar Zadeh, Bridget Anne Kirwan, Giovanni Mantovani, MUSCARITOLI, Maurizio, Anne B. Newman, ROSSI FANELLI, Filippo, Giuseppe M. c. Rosano, Ronenn Roubenoff, Morris Schambelan, Sokol Gh, Thomas W. Storer, Bruno Vellas, Stephan Von Haehling, Shing Shing Yeh, Stefan D. Anker, O. n. Sarcopenia The Society, Cachexia, Wasting Disorders Trialist Workshop   +33 more
openaire   +5 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Movement smoothness during a functional mobility task in subjects with Parkinson’s disease and freezing of gait – an analysis using inertial measurement units

Journal of NeuroEngineering and Rehabilitation, 2019
Background Impairments of functional mobility may affect locomotion and quality of life in subjects with Parkinson’s disease (PD). Movement smoothness measurements, such as the spectral arc length (SPARC), are novel approaches to quantify movement ...
Camila Pinto, Clarissa Pedrini Schuch, Gustavo Balbinot, Ana Paula Salazar, Ewald Max Hennig, Ana Francisca Rozin Kleiner, Aline Souza Pagnussat   +6 more
doaj   +1 more source

Independent living program evaluation for Rebuilding All Goals Efficiently

, 2011
This paper evaluates the outcome of independent living (IL) services provided to clients with Spinal Cord Injuries (SCI) by a local non-profit organization, Rebuilding All Goals Efficiently (RAGE).
Armour, Patricia, Moulton, Debra, Pruett, Araceli   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source