Results 11 to 20 of about 7,920 (199)
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease [PDF]
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
openalex +2 more sources
Assessing Condition-Specific Adverse Event Profiles of Modafinil for Labelled and Off-Label Uses: A Systematic Review and Meta-Analysis. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jung J +5 more
europepmc +2 more sources
Pharmacologic Treatment of Kleine-Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options. [PDF]
Neuropsychopharmacol RepA 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Thawongit S +2 more
europepmc +2 more sources
The off-prescription use of modafinil: An online survey of perceived risks and benefits.
PLoS ONE, 2020 Cognitive enhancing drugs are claimed to improve cognitive functions such as learning and attention. However, little is known presently about the characteristics of off-prescription cognitive enhancing drug users or their perceived everyday experience ...
Rachel D Teodorini +2 more
doaj +1 more source
Use of Modafinil in Psychiatric Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2016 Modafinil, is a psychostimulant drug with neurochemical and behavourial effects, distinct from those of amphetamine. It is used to treat patients with narcolepsy and other excessive sleepiness.
Mehmet Hanifi Kokacya +3 more
doaj +1 more source
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Frontiers in Neuroscience, 2022 Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD.
Xiangyang Xiong +16 more
doaj +1 more source
Modafinil Improves Catalepsy in a Rat 6-Hydroxydopamine Model of Parkinson’s Disease; Possible Involvement of Dopaminergic Neurotransmission [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Modafinil is a vigilance-enhancing drug licensed for narcolepsy. The use of modafinil leads to various neuromodulatory effects with very low abuse potential. A body of evidence suggested that modafinil may have anti-parkinsonian effects.
Reza Vajdi-Hokmabad +4 more
doaj +1 more source
Frontiers in Psychiatry, 2023 IntroductionDespite advances in the treatment of bipolar disorder (BD), most patients do not achieve complete inter-episode recovery and functional disability is common.
Jessica M. Lipschitz +11 more
doaj +1 more source
Journal of Pharmacological Sciences, 2018 Treatment with dopaminergic agents result excessive daytime sleepiness (EDS) and some studies have shown the benefit of using modafinil for treating excessive daytime sleepiness of Parkinson's disease (PD) patient.
Rina Ando +9 more
doaj +1 more source
Effects of Modafinil on Behavioral Learning and Hippocampal Synaptic Transmission in Rats [PDF]
International Neurourology Journal, 2015 Purpose: Modafinil is a wake-promoting agent that has been proposed to improve cognitive performance at the preclinical and clinical levels. Since there is insufficient evidence for modafinil to be regarded as a cognitive enhancer, the aim of this study ...
Wen-Wen Yan +7 more
doaj +1 more source