Results 21 to 30 of about 7,920 (199)
PLoS ONE, 2013 BackgroundModafinil is a novel wake-promoting agent approved by the FDA ameliorating excessive daytime sleepiness (EDS) in three disorders: narcolepsy, shift work sleep disorder and obstructive sleep apnea.
Ping Sheng +7 more
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Modafinil-induced Fixed Drug Eruption
Indian Journal of Psychological Medicine, 2012 Modafinil is a stimulant drug widely used to promote wakefulness in a variety of psychiatric and neurological conditions. Modafinil-induced severe dermatologic reactions are uncommon but serious side effects.
Girish Vasant Gaikwad +1 more
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Roles of adrenergic α1 and dopamine D1 and D2 receptors in the mediation of the desynchronization effects of modafinil in a mouse EEG synchronization model. [PDF]
PLoS ONE, 2013 BACKGROUND: Synchronized electroencephalogram (EEG) activity is observed in pathological stages of cognitive impairment and epilepsy. Modafinil, known to increase the release of catecholamines, is a potent wake-promoting agent, and has shown some ...
Chang-Rui Chen +5 more
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Frontiers in Pharmacology, 2019 Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects ...
Raphael Wuo-Silva +12 more
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Frontiers in Pharmacology, 2016 There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and used indiscriminately by healthy individuals due to its positive effects on ...
Raphael Wuo-Silva +17 more
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High resolution mapping of modafinil induced changes in glutamate level in rat brain. [PDF]
PLoS ONE, 2014 Modafinil is marketed in the United States for the treatment of narcolepsy and daytime somnolence due to shift-work or sleep apnea. Investigations of this drug in the treatment of cocaine and nicotine dependence in addition to disorders of executive ...
Mohammad Haris +9 more
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The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. [PDF]
PLoS ONE, 2011 Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction.
Kyle C Schmitt, Maarten E A Reith
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Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions
Frontiers in Neurology, 2013 Modafinil, in its two clinical formulations (Provigil® and Nuvigil®), is a widely prescribed wake-promoting therapeutic agent. It binds competitively to the cell membrane dopamine transporter and is dependent on catecholaminergic (dopaminergic ...
Jonathan P Wisor
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Journal of Pharmacy & Pharmaceutical Sciences, 2010 Purpose. The pharmacokinetics of modafinil were investigated in relation to gender and ethnicity in healthy young volunteers from Han, Mongolian, Korean, Uygur and Hui ( n = 10/group) following administration of a single 200 mg oral dose. Methods.
Tao Guo, Longshan Zhao, Dong-Ya Xia
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Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. [PDF]
PLoS ONE, 2012 Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine ...
Mariana Raineri +7 more
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