Results 61 to 70 of about 6,043 (157)

Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation

Frontiers in Cellular Neuroscience, 2018
Background: Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders.
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani   +9 more
doaj   +1 more source

Short- and Long-Term Efficacy of Modafinil at Improving Quality of Life in Stroke Survivors: A Post Hoc Sub Study of the Modafinil in Debilitating Fatigue After Stroke Trial

Frontiers in Neurology, 2018
BackgroundThe phase-II modafinil in debilitating fatigue after stroke trial demonstrated that modafinil improves fatigue and quality of life in severely fatigued stroke survivors.
Thomas P. Lillicrap, Thomas P. Lillicrap, Christopher R. Levi, Christopher R. Levi, Elizabeth Holliday, Mark William Parsons, Mark William Parsons, Andrew Bivard, Andrew Bivard   +8 more
doaj   +1 more source

The use of modafinil for the treatment of fatigue in multiple sclerosis: A systematic review and meta‐analysis of controlled clinical trials

Brain and Behavior
Introduction Multiple sclerosis (MS) is a debilitating neurological condition affecting nearly one million people across the United States. Among the most prominent symptoms of the condition are excessive fatigue and daytime sleepiness. Numerous clinical
Shamas Ghazanfar, Minaam Farooq, Shurjeel Uddin Qazi, Bipin Chaurasia, Ulrike Kaunzner   +4 more
doaj   +1 more source

Alterations in the hepatic drug-metabolizing enzyme network of mice induced by +Gz exposure and its impact on the pharmacokinetics and pharmacodynamics of modafinil

Frontiers in Pharmacology
BackgroundIn aviation and aerospace missions, personnel and astronauts are subjected to brief episodes of +Gz acceleration, resulting in overload stress that adversely affects the cardiovascular, respiratory, and nervous systems.
Fengzhou Liu, Fengzhou Liu, Fengzhou Liu, Hui Shen, Qun Wan, Yajuan Li, Gang Zhao, Xiao Liu, Wei Lin, Junhui Xue, Junhui Xue, Junhui Xue   +11 more
doaj   +1 more source

Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics

ADMET and DMPK
Introduction: Modafinil, a wakefulness-promoting agent, is primarily used to treat excessive daytime sleepiness associated with narcolepsy and fatigue. As a BCS class II drug, modafinil exhibits low solubility and high permeability, with its crystalline
Derar Omari, Assayed Sallam, Iyad Rashid, Shereen M. Assaf, Faisal Akayleh, Khaldoun A. Al-Sou′od   +5 more
doaj   +1 more source

Comparative efficacy, safety and benefit/risk of alerting agents for excessive daytime sleepiness in patients with obstructive sleep apnoea: a network meta-analysisResearch in context

EClinicalMedicine
Summary: Background: Obstructive sleep apnoea (OSA) is a common chronic respiratory disease associated with a high burden of disabilities related to sleepiness and reduced quality of life.
Jean-Louis Pépin, Philippe Lehert, Raoua Ben Messaoud, Marie Joyeux-Faure, Christian Caussé, Jerryll Asin, Ferran Barbé, Maria R. Bonsignore, Winfried Randerath, Johan Verbraecken, Sonya Craig, Yves Dauvilliers   +11 more
doaj   +1 more source

Modafinil Induced Psychosis in a Patient with Recurrent Depressive Disorder: A Case Report

Kerala Journal of Psychiatry
BACKGROUND: Modafinil is the first FDA-designated “wakefulness-promoting agent” and is approved for use as an adjuvant in mood disorders. In depressive disorders, it is reported to be effective in alleviating fatigue and related symptoms. The molecule is
Gopika SS, Diya P Albert, Vidhukumar Karunakaran   +2 more
doaj   +1 more source

Perceived cognitive performance in off‐prescription users of modafinil and methylphenidate: an online survey

Brain and Behavior
Introduction Modafinil and methylphenidate are used off‐prescription for cognitive enhancement in healthy individuals. Such use is often reported in online surveys but it is unclear whether drug use for cognitive enhancement is motivated by perceived ...
Rachel D. Teodorini, Nicola Rycroft, James H. Smith‐Spark   +2 more
doaj   +1 more source

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

Biomolecules
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g ...
Kuo-Hao Lee, Gisela Andrea Camacho-Hernandez, Amy Hauck Newman, Lei Shi   +3 more
doaj   +1 more source

Evaluation of the effect of Modafinil in the improvement of the level of consciousness in patients with COVID‐19 encephalopathy: A randomized controlled trial

Neuropsychopharmacology Reports
Aim COVID‐19 can lead to encephalopathy and loss of consciousness. This double‐blinded randomized clinical trial conducted in Tehran, Iran, aimed to assess the potential effectiveness of modafinil in patients with COVID‐19‐related encephalopathy. Methods
Fatemeh Talebi Kiasari, Mobin Naghshbandi, Maziar Emamikhah, Omid Moradi Moghaddam, Mohammad Niakan Lahiji, Mohammad Rohani, Narges Yazdi, Hamidreza Movahedi, Alireza Amanollahi, Pardis Irandoost, Roya Ghafoury   +10 more
doaj   +1 more source