Results 61 to 70 of about 8,589 (193)

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review integrates three hierarchical frameworks—ascending reticular activating system (ARAS), mesocircuit hypothesis, and intrinsic connectivity networks (ICNs)—to update the neural mechanisms of disorders of consciousness (DoC). We highlight emerging evidence for glutamatergic ARAS pathways, a bidirectional GPi–GPe mesocircuit regulating ...
Yichen Zhou, Tianqing Cao, Sipeng Zhu, Qiheng He, Yitong Jia, Xiaoke Chai, Nan Wang, Yi Yang   +7 more
wiley   +1 more source

Hypothalamic Arousal Regions Are Activated during Modafinil-Induced Wakefulness

, 2000
Modafinil is an increasingly popular wake-promoting drug used for the treatment of narcolepsy, but its precise mechanism of action is unknown. To determine potential pathways via which modafinil acts, we administered a range of doses of modafinil to rats,
Thomas E. Scammell, Richard M. Chemelli, Matthew S. Miller, Marie T. McCarthy, Clifford B. Saper, Ivy V. Estabrooke, Masashi Yanagisawa   +6 more
core   +1 more source

Assessing mortality risk in narcolepsy: Evidence from population studies

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Narcolepsy is a chronic neurologic sleep disorder associated with excessive daytime sleepiness, cataplexy, and a higher prevalence of cardiovascular and psychiatric comorbidities. While these factors may predispose individuals to adverse events, observational studies evaluating mortality in narcolepsy have yielded inconsistent results.
Nawris Alhassan, Susmin Karki, Jagdish Lal   +2 more
wiley   +1 more source

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, Volume 18, Issue 9, Page 1005-1015, September 2026.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. [PDF]

, 2010
Item does not contain fulltextBACKGROUND: Early recovery of patients following sedation/analgesia and anesthesia is important in ambulatory practice. The aim of this study was to assess whether modafinil, used for the treatment of narcolepsy, improves ...
Klein, J., Ubben, J.F., Galvin, E.; id_orcid, Verbrugge, S. J.C., Verbrugge, S.J., Boesjes, H., Klein-Nulend, J., Galvin, E., Hol, J., Ubben, J. F., E. GALVIN, H. BOESJES, J. F. UBBEN, J. HOL, S. J. C. VERBRUGGE, J. KLEIN   +15 more
core   +1 more source

Cerebrospinal fluid orexin testing in Australians with narcolepsy type 1

Internal Medicine Journal, Volume 56, Issue 9, Page 1641-1643, September 2026.
Abstract A clinical diagnosis of narcolepsy type 1 can be challenging, particularly in relation to cataplexy. Despite its specificity, cerebrospinal fluid (CSF) orexin testing is under‐utilised in Australasia. We describe the use of CSF orexin testing in 15 clinically indicated patients from two sleep centres, highlighting its utility in the ...
Mario Fernando, Gianluca Cotta, Samantha Kung, Grace Garden, Jian Eu Tai, Elie Matar, Brendon Yee, Claire Ellender, Sheila Sivam   +8 more
wiley   +1 more source

Behavioral Changes in Combination Therapy of Ethanol and Modafinil on rats Focal Cerebral Ischemia

Basic and Clinical Neuroscience, 2020
Introduction: Ethanol is considered as an effective agent in reducing brain stroke injury. In this study, we assessed the effects of modafinil along with ethanol as a combination therapy on behavioral function in Wistar rats.
Yusef Abbasi, Kazem Mousavizadeh, Ronak Shabani, Majid Katebi, Mehdi Mehdizadeh   +4 more
doaj  

The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze

Frontiers in Behavioral Neuroscience, 2015
A series of drugs have been reported to increase memory performance modulating the dopaminergic system and herein modafinil was tested for its working memory (WM) enhancing properties. Reuptake inhibition of dopamine, serotonin (SERT) and norepinephrine (
Yasemin eKarabacak, Sunetra eSase, Yogesh eAher, Ajinkya eSase, Sivaprakasam eSaroja, Ana eCicvaric, Harald eHoeger, Michael eBerger, Vasiliy eBakulev, Harald H Sitte, Johann eLeban, Francisco J Monje, Gert eLubec   +12 more
doaj   +1 more source

Long‐term outcomes in patients with postural orthostatic tachycardia syndrome with an average follow‐up of over 20 years

Journal of Internal Medicine, Volume 300, Issue 3, Page 299-311, September 2026.
Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily affects female patients. There are scarce data evaluating the long‐term outcomes in POTS. Objectives This study sought to evaluate the long‐term impacts of POTS over multiple decades in adult patients.
Kate M. Bourne, Alfredo Gamboa, Bonnie Black, Juliette Hall, Italo Biaggioni, Cyndya A. Shibao, André Diedrich, Amanda Peltier, Giris Jacob, Luis Okamoto, Robert S. Sheldon, Satish R. Raj   +11 more
wiley   +1 more source

Modafinil and modafinil analogues: free radical mechanism of the eugeroic and cognitive enhancment effect

, 2018
Evidence is presented that strongly implicates the involvement of free radical species in the eugeroic and cognitive enhancement ability of modafinil and modafinil-like analogues via a dissociative electron transfer (DET) or attachment mechanism ...
Fong, Clifford, W
core   +2 more sources