Results 81 to 90 of about 7,733 (194)

Effects of acute modafinil on cognition in trichotillomania

, 2010
Rationale Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair. Objectives The aim of this study is to examine whether modafinil improves motor inhibitory control, and other cognitive functions,
Ulrich Müller, Jon E. Grant, Barbara J. Sahakian, Costa, Anna, Grant, Jon E., Sahakian, Barbara J., Samuel R. Chamberlain, Chamberlain, Samuel R., Müller, Ulrich, Anna Costa   +9 more
core   +1 more source

Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation

Frontiers in Cellular Neuroscience, 2018
Background: Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders.
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani   +9 more
doaj   +1 more source

Short- and Long-Term Efficacy of Modafinil at Improving Quality of Life in Stroke Survivors: A Post Hoc Sub Study of the Modafinil in Debilitating Fatigue After Stroke Trial

Frontiers in Neurology, 2018
BackgroundThe phase-II modafinil in debilitating fatigue after stroke trial demonstrated that modafinil improves fatigue and quality of life in severely fatigued stroke survivors.
Thomas P. Lillicrap, Thomas P. Lillicrap, Christopher R. Levi, Christopher R. Levi, Elizabeth Holliday, Mark William Parsons, Mark William Parsons, Andrew Bivard, Andrew Bivard   +8 more
doaj   +1 more source

The use of modafinil for the treatment of fatigue in multiple sclerosis: A systematic review and meta‐analysis of controlled clinical trials

Brain and Behavior
Introduction Multiple sclerosis (MS) is a debilitating neurological condition affecting nearly one million people across the United States. Among the most prominent symptoms of the condition are excessive fatigue and daytime sleepiness. Numerous clinical
Shamas Ghazanfar, Minaam Farooq, Shurjeel Uddin Qazi, Bipin Chaurasia, Ulrike Kaunzner   +4 more
doaj   +1 more source

Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics

ADMET and DMPK
Introduction: Modafinil, a wakefulness-promoting agent, is primarily used to treat excessive daytime sleepiness associated with narcolepsy and fatigue. As a BCS class II drug, modafinil exhibits low solubility and high permeability, with its crystalline
Derar Omari, Assayed Sallam, Iyad Rashid, Shereen M. Assaf, Faisal Akayleh, Khaldoun A. Al-Sou′od   +5 more
doaj   +1 more source

Impact of Astroglial Connexins on Modafinil Pharmacological Properties

, 2016
International audienceSTUDY OBJECTIVES:Modafinil is a non-amphetaminic wake-promoting compound used as therapy against sleepiness and narcolepsy. Its mode of action is complex, but modafinil has been recently proposed to act as a cellular-coupling ...
Dauvilliers, Yves, M, Piérard, Christophe, Dauvilliers, Yves,, Mouthon, Franck, Chauveau, Frédéric, Liu, Xinhe, Lin, Jian-Sheng, Thomasson, Julien, Lagarde, Didier, Giaume, Christian, Charvériat, Mathieu, Perier, Magali, Duchêne, Adeline, Zhao, Yan, Jeanson, Tiffany, Picoli, Christèle   +15 more
core   +1 more source

Comparative efficacy, safety and benefit/risk of alerting agents for excessive daytime sleepiness in patients with obstructive sleep apnoea: a network meta-analysisResearch in context

EClinicalMedicine
Summary: Background: Obstructive sleep apnoea (OSA) is a common chronic respiratory disease associated with a high burden of disabilities related to sleepiness and reduced quality of life.
Jean-Louis Pépin, Philippe Lehert, Raoua Ben Messaoud, Marie Joyeux-Faure, Christian Caussé, Jerryll Asin, Ferran Barbé, Maria R. Bonsignore, Winfried Randerath, Johan Verbraecken, Sonya Craig, Yves Dauvilliers   +11 more
doaj   +1 more source

Modafinil decreases anxiety-like behaviour in zebrafish

, 2017
Modafinil (2-((diphenylmethyl)sulfinyl)acetamide), a selective dopamine and norepinephrine transporter inhibitor, is most commonly prescribed for narcolepsy but has gained recent interest for treating a variety of disorders.
Adrian Johnson, Trevor James Hamilton
core   +1 more source

Is the use of modafinil, a pharmacological cognitive enhancer, cheating?

, 2018
Drugs used to provide improvement of cognitive functioning have been shown to be effective in healthy individuals. It is sometimes assumed that the use of these drugs constitutes cheating in an academic context.
Thomas Cochrane, Sebastian Porsdam Mann, Mitchell, Christine, Christine Mitchell, Pablo de Lora Deltoro, Porsdam Mann, Sebastian, de Lora Deltoro, Pablo, Cochrane, Thomas   +7 more
core   +1 more source

NAc core lesion reduces sleep latency following modafinil administration.

, 2013
Examples of polygraphic recordings and corresponding hypnograms in control, NAc core and shell lesioned rats treated with vehicle (A, C and E) and modafinil at the dose of 90 mg/kg (B, D and F).
Zhi-Li Huang (306746), Jun Lu (36049), Wei Liu (20030), Wei-Min Qu (306745), Mei-Hong Qiu (306744), Yoshihiro Urade (152776)   +5 more
core   +1 more source