The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g ...
Kuo-Hao Lee +3 more
doaj +1 more source
Effect of modafinil on simulated driving performance
Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide, Modavigil¬¨vÜ) is a novel stimulant medication shown to improve alertness, cognitive performance and subjective mood.
Hartley, J (15927056)
core +1 more source
Background Recent studies have shown that sleep disturbances are frequent at different stages of psychosis, including clinical high risk for psychosis (CHR‐P). However, the comorbidity of hypersomnia with CHR‐P and its treatment have rarely been reported
Yutaro Sato +2 more
doaj +1 more source
Modafinil improves primary nocturnal enuresis in multiple sclerosis
We report the case of two patients with multiple sclerosis (MS) and primary nocturn enuresis (PNE) treated with modafinil for MS-induced fatigue with improvement of enuretic episodes.
de Leva M. F. +3 more
core
Aim COVID‐19 can lead to encephalopathy and loss of consciousness. This double‐blinded randomized clinical trial conducted in Tehran, Iran, aimed to assess the potential effectiveness of modafinil in patients with COVID‐19‐related encephalopathy. Methods
Fatemeh Talebi Kiasari +10 more
doaj +1 more source
Modafinil bij psychiatrische aandoeningen : de veelbelovende status opnieuw bekeken
: achtergrond Modafinil, een stimulerend middel dat de waakzaamheid bevordert bij narcolepsie en daarnaast ook cognitieve functies versterkt, heeft in de psychiatrie reeds twee decennia de status van een veelbelovend product.
Sabbe, B.G.C. +4 more
core +1 more source
Kleine-Levine syndrome in an adolescent female and response to modafinil
Kleine-Levine Syndrome (KLS) is a disorder characterized by a triad of periodic hypersomnia, hyperphagia, and hypersexuality. KLS, although more common in young males, it has also been seen in females.
Aggarwal Ashish, Garg Amit, Jiloha R
doaj
Prenatal Exposure to Modafinil and the Risk of Major Congenital Anomalies and Other Adverse Neonatal and Pediatric Outcomes. [PDF]
Kanoun M +3 more
europepmc +1 more source
Caffeine and modafinil counteract sleep deprivation through distinct neurocognitive pathways: an ERP study of object working memory. [PDF]
Shao Y +7 more
europepmc +1 more source
Management of shift work disorder: an American Academy of Sleep Medicine clinical practice guideline. [PDF]
Wright KP +11 more
europepmc +1 more source

