Results 81 to 90 of about 1,019,487 (291)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

New Silica Laser-Optimized Multimode Optical Fibers with Extremely Enlarged 100-μm Core Diameter for Gigabit Onboard and Industrial Networks

Fibers, 2020
We present new type of silica graded index laser-optimized multimode optical fibers (LOMF) with extremely enlarged core diameter up to 100 μm and “typical” “telecommunication” cladding diameter 125 μm. This optical fiber
Vladimir A. Burdin, Michael V. Dashkov, Vladimir V. Demidov, Konstantin V. Dukelskii, Alexander S. Evtushenko, Artem A. Kuznetsov, Alexandra S. Matrosova, Oleg G. Morozov, Egishe V. Ter-Nersesyants, Alexander A. Vasilets, Elena S. Zaitseva, Alexander E. Zhukov, Anton V. Bourdine   +12 more
doaj   +1 more source

Electron-phonon interaction in the t-J model

, 2004
We derive a t-J model with electron-phonon coupling from the three-band model, considering modulation of both hopping and Coulomb integrals by phonons.
K. J. von Szczepanski, L. Pintschovius, O. Gunnarsson, O. Rösch, O. K. Andersen, Y. Inada, Z.-X. Shen   +6 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Applicability of Bispectral Analysis to Causality Determination within and between Ensembles of Unstable Plasma Waves

Atoms
Turbulence implies nonlinear wave–wave coupling, and determining cause and effect of either is important to understand mixing responsible for enhanced number, momentum, or energy (NME) transport. To explain the identification of parent and daughter modes
Renaud Stauber, Mark Koepke
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Gravity-driven instability in a spherical Hele-Shaw cell

, 2000
A pair of concentric spheres separated by a small gap form a spherical Hele-Shaw cell. In this cell an interfacial instability arises when two immiscible fluids flow.
B. A. Dubrovin, D. Bensimon, Fernando Moraes, Fernando Parisio, G. Homsy, G. I. Taylor, J. A. Miranda, José A. Miranda, K. V. McCloud, L. W. Schwartz, Ll. Carrillo, Michael Widom, P. G. Saffman, R. E. Rosensweig, S. Chandrashekhar, S. Richardson   +15 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Design and Characterization of Nanopore- Assisted Weakly-Coupled Few-Mode Fiber for Simpler MIMO Space Division Multiplexing

IEEE Access, 2020
We report on a novel weakly-coupled 6-LP-mode fiber that features a nanopore-assisted step-index core with double-cladding profile. The purpose of this fiber design is to alleviate modes coupling and bend sensitivity, thus simplifies the multiple-input ...
Yuheng Xie, Li Pei, Jingjing Zheng, Tigang Ning, Jing Li, Bo Ai, Ruisi He   +6 more
doaj   +1 more source