Results 61 to 70 of about 118,827 (219)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Determination of mode shapes of a multiple cracked beam element and its application for free vibration analysis of a multi-span continuous beam

Vietnam Journal of Mechanics, 2013
This article presents some results on the determination of the vibration shape function of a multiple cracked elastic beam element, which is modeled as an assembly of intact sub-segments connected by massless rotational springs.
Tran Van Lien, Trinh Anh Hao
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Efficacy of Vehicle Scanning Methods in Estimating the Mode Shapes of Bridges Seated on Elastic Supports. [PDF]

Sensors (Basel), 2023
Demirlioglu K, Gonen S, Erduran E.
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Changes in Frequency and Mode Shapes Due to Damage in Steel-Concrete Composite Beam. [PDF]

Materials (Basel), 2021
Jarosińska M, Berczyński S.
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Stiffness estimation for large–sized umbrella space reflector

MATEC Web of Conferences, 2016
This work describes stiffness estimation for new large-sized (with aperture more than 50 m) umbrella space reflector. Reflector stiffness is measured by natural frequencies.
Belkov Alexey, Belov Sergey, Pavlov Mikhail, Ponomarev Victor, Ponomarev Sergey, Zhukov Andrey   +5 more
doaj   +1 more source

Delivery Mode Shapes the Composition of the Lower Airways Microbiota in Newborns. [PDF]

Front Cell Infect Microbiol, 2021
Cardelli E, Calvigioni M, Vecchione A, Macera L, Mazzantini D, Celandroni F, Panattoni A, Pistello M, Maggi F, Ghelardi E, Mannella P.   +10 more
europepmc   +1 more source