Results 91 to 100 of about 4,021,533 (345)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Model-Based System Engineering Adoption in the Vehicular Systems Domain [PDF]

Annals of computer science and information systems, 2022
Henrik Gustavsson, Jan Carlson, Eduard Enoiu   +2 more
doaj   +1 more source

Exertional Heat Strain Detection: Application of the Human Performance Model Based Systems Engineering System Architecture (MBSE‐SA) [PDF]

, 2023
Tara Sarathi, Heather Morris, Paula Collins, Michael P. Shatz   +3 more
openalex   +1 more source

Enhanced Data Integration for LabVIEW Laboratory Systems

, 2013
Integrating data is a basic concern in many accredited laboratories that perform a large variety of measurements. However, the present working style in engineering faculties does not focus much on this aspect. To deal with this challenge, we developed an
Ionita, Anca Daniela, Olteanu, Adriana, Sgarciu, Valentin, Stamatescu, Grigore   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Modeling- and Simulation-Driven Methodology for the Deployment of an Inland Water Monitoring System

Information
In response to the challenges introduced by global warming and increased eutrophication, this paper presents an innovative modeling and simulation (M&S)-driven model for developing an automated inland water monitoring system. This system is grounded in a
Giordy A. Andrade, Segundo Esteban, José L. Risco-Martín, Jesús Chacón, Eva Besada-Portas   +4 more
doaj   +1 more source

Teaching Systems Thinking and System Dynamics in Engineering, Ecology and Environmental Sciences: A Concise Course Based on the Water Management and Population Dynamics Models

, 2023
Vladimir Krivtsov, Irene Pluchinotta, Alessandro Pagano   +2 more
openalex   +1 more source

Engineering model system study for a regenerative fuel cell: Study report [PDF]

Key design issues of the regenerative fuel cell system concept were studied and a design definition of an alkaline electrolyte based engineering model system or low Earth orbit missions was completed.
Chang, B. J., Kovach, A. J., Schubert, F. H., Wynveen, R. A.   +3 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A Systems Thinking Approach to Designing Clinical Models and Healthcare Services

Systems, 2019
Chronic diseases are on the rise, increasing in number and treatment regimen complexity. Consequently, the needs of patients with chronic diseases are increasing and becoming more complex and multi-faceted.
Inas S. Khayal
doaj   +1 more source