Results 71 to 80 of about 4,021,533 (345)

Study on the overall design method of ship power system engineering based on MBSE

open access: yesZhongguo Jianchuan Yanjiu, 2023
In order to improve the overall positive design ability of ship power engineering, the digital design method of ship power systems engineering is studied. The model-based systems engineering (MBSE) method theory was integrated with the system engineering
Yuanlong YANG   +3 more
doaj   +1 more source

Ontology and Model Based Systems Engineering

open access: yesProcedia Computer Science, 2011
The subject of this paper is an information technology framework based on the use of an ontology that can be used for explicit and consistent specification, design, engineering, production and maintenance of complex facilities, e.g. ships and infrastructure.
openaire   +1 more source

A Practical Environment to Apply Model-Driven Web Engineering [PDF]

open access: yes, 2009
The application of a model-driven paradigm in the development of Web Systems has yielded very good research results. Several research groups are defining metamodels, transformations, and tools which offer a suitable environment, known as model-driven ...
Escalona Cuaresma, María José   +7 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

On Formal Methods for Collective Adaptive System Engineering. {Scalable Approximated, Spatial} Analysis Techniques. Extended Abstract

open access: yes, 2016
In this extended abstract a view on the role of Formal Methods in System Engineering is briefly presented. Then two examples of useful analysis techniques based on solid mathematical theories are discussed as well as the software tools which have been ...
Latella, Diego
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Appropriate Models In Decision Support Systems For River Basin Management [PDF]

open access: yes, 2004
In recent years, new ideas and techniques appear very quickly, like sustainability, adaptive management, Geographic Information System, Remote Sensing and participations of new stakeholders, which contribute a lot to the development of decision support ...
Booij, Martijn J., Xu, Yueping
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Constructing True Model-Based Requirements in SysML

open access: yesSystems, 2019
Some authors suggest that transitioning requirements engineering from the traditional statements in natural language with shall clauses to model-based requirements within a Model-Based Systems Engineering (MBSE) environment could improve communication ...
Alejandro Salado, Paul Wach
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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