Results 81 to 90 of about 4,021,533 (345)

Early Design Space Exploration with Model-Based System Engineering and Set-Based Design

Systems, 2018
Adequately exploring the tradespace in the early system design phase is important to determine the best design concepts to pursue in the next life cycle stage. Tradespace exploration (TSE) often uses trade-off analysis.
Eric Specking, Gregory Parnell, Edward Pohl, Randy Buchanan   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Goal-based self-contextualization [PDF]

, 2009
. System self-contextualizability is the system ability to autonomously adapt its behavior to the uncontrollable relevant context to keep its objectives satisfied.
Ali, Raian, Dalpiaz, Fabiano, Giorgini, Paolo   +2 more
core   +2 more sources

On the critical nature of plastic flow: one and two dimensional models

, 2012
Steady state plastic flows have been compared to developed turbulence because the two phenomena share the inherent complexity of particle trajectories, the scale free spatial patterns and the power law statistics of fluctuations.
Acharya, Ananthakrishna, Argon, Bak, Baret, Barnsley, Ben-Zion, Ben-Zion, Berdichevsky, Bharathi, Bharathi, Blanc, Born, Braides, Brinckmann, Bréchet, Cahn, Cahn, Carpio, Carpio, Carrillo, Chan, Charlotte, Chen, Chen, Chen, Choi, Ciamarra, Clauset, Colaiori, Colaiori, Conti, Cottrell, Cottrell, Csikor, Dahmen, Dahmen, Dahmen, Delaplace, Dhar, Dhar, Dickman, Dimiduk, Dimiduk, Falk, Fedelich, Fey, Fisher, Fisher, Fisher, Fressengeas, Groma, Hamon, Henkel, Hentschel, Hill, Hirth, Houston, Hwa, Hähner, Ispánovity, Jakobsen, Jarai, Jensen, Kachanov, Kardar, Kartha, Kertesz, Kobayashi, Koslowski, Koslowski, Koslowski, Kovalev, Kresse, Kubin, Kubin, Kuntz, L. Truskinovsky, Landau, Landau, Laurson, Laurson, Le Doussal, Le Doussal, Limkumnerd, Limkumnerd, Limkumnerd, Liu, Lookman, Lubliner, Maeda, Maeda, Malandro, Maloney, Maloney, Maslov, Mehta, Mielke, Miguel, Miguel, Miyazaki, Moretti, Motz, Mueller, Mughrabi, Nabarro, Nabarro, Nadgorny, Narayan, Needleman, Ng, O.U. Salman, Onuki, Ortiz, Pagano, Papanikolaou, Patinet, Pellegrini, Pertsinidis, Plans, Prandtl, Procaccia, Puglisi, Puglisi, Puglisi, Pérez-Reche, Pérez-Reche, Pérez-Reche, Pérez-Reche, Rasmussen, Redig, Ren, Rice, Richeton, Richeton, Richeton, Rogers, Roy, Salman, Seeger, Sethna, Sethna, Shishvan, Sornette, Suziki, Talamali, Tanguy, Truskinovsky, Truskinovsky, Truskinovsky, Turcotte, Vainchtein, Vives, Weiss, Weiss, Weiss, Weiss, Weiss, Yamamoto, Zaiser, Zaiser, Zaiser, Zaiser, Zaiser, Zaiser, Zapperi, Zhou   +166 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source