Results 101 to 110 of about 3,497,010 (299)

Optimizing additive manufacturing workflows using model-based systems engineering

Results in Engineering
Additive Manufacturing (AM) is a transformative technology enabling the production of complex geometries with reduced waste and lead times. However, optimizing AM workflows involves addressing challenges such as design validation, process parameters, and
Mohamed Amine Daoud, Khadija Bekkay Haouari, Meriem Hayani Mechkouri, Amine Ennawaoui, Hicham El hadraoui, Ilias Naser, Mustapha Ouardouz, Kamal Reklaoui   +7 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ensuring Semantic Consistency in SysML v2 Models Through Metamodel-Driven Validation

IEEE Access
Model-Based Systems Engineering (MBSE) relies on formal models for system lifecycle management, supporting model coherence and efficient reuse of components.
Eduardo Cibrian, Jose Olivert-Iserte, Carlos Diez-Fenoy, Roy Mendieta, Juan Llorens, Jose Maria Alvarez-Rodriguez   +5 more
doaj   +1 more source

Formal Model Engineering for Embedded Systems Using Real-Time Maude

, 2011
This paper motivates why Real-Time Maude should be well suited to provide a formal semantics and formal analysis capabilities to modeling languages for embedded systems.
A. Boronat, A. Boronat, A. Boronat, A. Boronat, A. Cerone, E. Lien, F. Wang, Francisco Durán, J. E. Rivera, J. E. Rivera, J. Eker, J. Meseguer, J. Srba, K. Bae, K. Bae, M. AlTurki, M. Clavel, M. Katelman, P. C. Ölveczky, P. C. Ölveczky, P. C. Ölveczky, P. C. Ölveczky, P. C. Ölveczky, P. C. Ölveczky, Peter Csaba Ölveczky, R. Alur, S. P. Miller, Vlad Rusu   +27 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Safe Neighborhood Computation for Hybrid System Verification

, 2015
For the design and implementation of engineering systems, performing model-based analysis can disclose potential safety issues at an early stage. The analysis of hybrid system models is in general difficult due to the intrinsic complexity of hybrid ...
Deng, Yi, Julius, Agung
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Model-Based Approach to Engineering Resilience in Multi-UAV Systems

Systems, 2019
Multi-UAV Operations are an area of great interest in government, industry, and research community. In multi-UAV operations, a group of unmanned aerial vehicles (UAVs) are deployed to carry out missions such as search and rescue or disaster relief.
Edwin Ordoukhanian, Azad M. Madni
doaj   +1 more source

A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems [PDF]

, 2017
Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products.
Domínguez-Mayo, F.J, Escalona, M.J, Martínez-García, A, Mejías , M, Olivero, M. A, Parra-Calderón , C. L, Suárez-Bote, A, Sánchez-Bejines, J.M   +7 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source