Results 81 to 90 of about 3,497,010 (299)
EGRESS: A Methodology for Eliciting Goals for Requirements Engineering of Secure Systems
IEEE Open Journal of Systems EngineeringCurrently, the systems engineering body of knowledge does not appropriately address secure system design considerations prior to a preliminary architecture being available for the system under design.
Martin Span, Gabe Salinger, Jeremy Daily
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
SystemsIn an increasingly complex world there is a real, urgent need for methodologies to enable engineers to model complex sociotechnical systems, as these now seem to describe the majority of systems in use today.
Rees Hill, David Slater
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
V-Model Role Engineering [PDF]
The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Seamless Function-Oriented Mechanical System Architectures and Models
EngOne major challenge of today’s product development is to master the constantly increasing product complexity driven by the interactions between different disciplines, like mechanical, electrical and software engineering.
Christian Wyrwich +6 more
doaj +1 more source
Reliability Analysis of Complex NASA Systems with Model-Based Engineering [PDF]
The emergence of model-based engineering, with Model- Based Systems Engineering (MBSE) leading the way, is transforming design and analysis methodologies.
Alimardani, Mahdi +2 more
core +1 more source
Building product suggestions for a BIM model based on rule sets and a semantic reasoning engine [PDF]
, 2015 The architecture, engineering and construction (AEC) industry today relies on different information systems and computational tools built to support and assist in the building design and construction.
Costa, Gonçal, Pauwels, Pieter
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source