Results 91 to 100 of about 151,713,588 (303)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Biomechanical Modeling of Cardiac Looping
The FASEB Journal, 2007 The objective of this study is to determine the role that mechanics plays in cardiac c‐looping, which is the process by which the initially straight heart tube bends ventrally and twists rightward into a c‐shaped tube. In particular, we show how linking computational (finite‐element) modeling to quantitative experimental measurements on chick embryos ...
openaire +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
A phenomenological magnetomechanical model for hysteresis loops
Physica B: Condensed MatterIn this work we propose a simple phenomenological model for magnetization curves of stressed samples. The effect of stress is introduced by scaling the arctangent function argument (magnetic field) proportionally to stress. The magnetization curve is modelled by one or two arctangent functions.
openaire +2 more sources
After our 2022 seminar with Marc Porée, and our 2023 seminar with Jeremy Elprin on Keats, Loop is proud to present the 2024 agrégation seminar: Claire Vial and Agnès Blandeau: On Sir Gawain and the Green Knight (text and film) Amélie Ducroux : On T.S ...
The LOOP team
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
IEEE AccessAccurate real-time temperature estimation of permanent-magnet synchronous motors is essential to prevent overheating and ensure reliable operation. To this end, electric and thermal models are often used due to their low computational burden.
Erick Axel Martinez-Rios +6 more
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source