Results 71 to 80 of about 673,572 (219)
Blood-brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication. [PDF]
Sci Rep, 2022 Chien CY, Xu L, Pacia CP, Yue Y, Chen H.
europepmc +1 more source
Experimental Study on the Effect of Human-in-the-loop Integration on Large Language Model-based Process Control in Additive Manufacturing [PDF]
한국정밀공학회지This study proposes a human-in-the-loop framework that integrates operator observations into a large language model (LLM) to control process parameters for defect handling in fused deposition modeling (FDM) 3D printing. Fully autonomous LLM-based control
Seongyoon Jeon, Taehwan Kim, Namhun Kim
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Modeling and Control of a Road Wheel Actuation Module in Steer-by-Wire System
ActuatorsSince the steer-by-wire system removes the mechanical connection and uses electrical signals to drive the system, it has the disadvantage of being less stable in the failure of parts or systems.
Insu Chung, Jungdai Choi, Kanghyun Nam
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Reduced-Order Model for Bearingless PMSMs in Hardware-in-the-Loop
EnergiesHigh production costs and extended development timelines pose significant challenges to the manufacturing of bearingless permanent magnet synchronous motors (BPMSMs). Moreover, uncertainties regarding the motor’s ability to generate suspension and torque
Lucas Selonke Klaas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source