Results 81 to 90 of about 1,743,272 (302)

MDSheet: a framework for model-driven spreadsheet engineering [PDF]

, 2012
In this paper, we present MDSHEET, a framework for the embedding, evolution and inference of spreadsheet models.
Cunha, Jácome Miguel Costa, Fernandes, João Paulo, Mendes, Jorge, Saraiva, João Alexandre   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Integrated Modeling, Simulation and Analysis Framework for Engineering Complex Systems

IEEE Access, 2019
The discipline of component-based modeling and simulation offers promising gains in reducing cost, time, and the complexity of model development through the (re)use of modular components.
Imran Mahmood, Tameen Kausar, Hessam S. Sarjoughian, Asad Waqar Malik, Naveed Riaz   +4 more
doaj   +1 more source

Model-driven Engineering IDE for Quality Assessment of Data-intensive Applications

, 2017
This article introduces a model-driven engineering (MDE) integrated development environment (IDE) for Data-Intensive Cloud Applications (DIA) with iterative quality enhancements.
Gil, Marc, Joubert, Christophe, Torres, Ismael   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A brief introduction to model-driven engineering

Tecnura, 2014
La crisis del software es un concepto que comenzó a utilizarse en 1968, en la primera conferencia organizada por la Organización del Tratado del Atlántico Norte (OTAN) en el desarrollo de software.
Vicente García Díaz, Edward Rolando Nüñez Valdez, Jordán Pascual Espada, B. Cristina Pelayo García Bustelo, Juan Manuel Cueva Lovelle, Carlos Enrique Montenegro Marín   +5 more
doaj  

Category Theory and Model-Driven Engineering: From Formal Semantics to Design Patterns and Beyond

, 2012
There is a hidden intrigue in the title. CT is one of the most abstract mathematical disciplines, sometimes nicknamed "abstract nonsense". MDE is a recent trend in software development, industrially supported by standards, tools, and the status of a new "
Antkiewicz, Batory, Bernstein, Bohannon, Boronat, Czarnecki, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Diskin, Ehrig, Fiadeiro, Fiadeiro, Fiadeiro, Fiadeiro, Foster, Goguen, Hermann, Hofmann, Johnson, Johnson, Johnson, Johnson, José Fiadeiro, Jurack, Liang, Makkai, Matsuda, Pottinger, Rossini, Rossini, Rutle, Rutle, Selic, Shaw, Spaccapietra, Stevens, Thomas Soboll, Tom Maibaum, Ulrike Golas, Xiong, Zinovy Diskin   +50 more
core   +3 more sources

Testing M2T/T2M Transformations [PDF]

, 2013
Presentado en: 16th International Conference on Model Driven Engineering Languages and Systems (MODELS 2013). Del 29 de septiembre al 4 de octubre. Miami, EEUU.Testing model-to-model (M2M) transformations is becoming a prominent topic in the current ...
A. García-Domínguez, A. Vallecillo, B. Baudry, B. Meyer, E. Guerra, E. Guerra, I. Stürmer, K. Czarnecki, M. Gogolla, M. Gogolla, P. Giner, R. Pérez-Castillo, R. Ramos, R. Straeten Van Der   +13 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Towards Guidelines for Preventing Critical Requirements Engineering Problems [PDF]

, 2016
Context] Problems in Requirements Engineering (RE) can lead to serious consequences during the software development lifecycle. [Goal] The goal of this paper is to propose empirically-based guidelines that can be used by different types of organisations ...
Felderer, M., Fernández, D. Méndez, Kalinowski, M., Mafra, P., Wagner, S.   +4 more
core   +2 more sources