Results 141 to 150 of about 739,145 (318)

On currents in the $O(n)$ loop model

SciPost Physics
Using methods from the conformal bootstrap, we study the properties of Noether currents in the critical $O(n)$ loop model. We confirm that they do not give rise to a Kac-Moody algebra (for $n≠ 2$), a result expected from the underlying lack of unitarity.
Jesper Lykke Jacobsen, Rongvoram Nivesvivat, Hubert Saleur
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Using an Ersatz Thermosiphon

, 2007
Natural convection loops (NCL) can occur when extracting energy from thermal storage with immersed heat exchangers. To assist in heat exchanger design and annual performance simulations of such systems, this paper proposes modeling an NCL with a ...
J. D. Burch, Loop To Model, K. M. Gawlik
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Counterfactual Medical Images Generation for Lung Disease Diagnosis Using Probabilistic Causal Models and Active Learning

IEEE Access
Recent advancements in deep learning have shown promise in diagnosing lung diseases from medical images, but these methods often lack causal inference capabilities, limiting their applicability in clinical decision-making.
Yifei Zhu, Lei Zhang, Chris Sainsbury, Feng Dong, John MacLay, David J. Lowe, Xujiong Ye   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Three-Loop Model of Neutrino Mass with Dark Matter

, 2016
We propose a model in which the origin of neutrino mass is dependent on the existence of dark matter. Neutrinos acquire mass at the three-loop level and the dark matter is the neutral component of a fermion triplet.
Ahriche, Amine;Chen, Chian-Shu;McDonald, Kristian L.;Nasri, Salah
core   +1 more source

First-Order Linear Mechatronics Model for Closed-Loop MEMS Disk Resonator Gyroscope. [PDF]

Sensors (Basel), 2020
Wang H, Wang X, Xie J.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source