Model in the loop - Open Access .click

Results 181 to 190 of about 739,145 (318)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak +2 more
wiley +1 more source

Improving the Dynamic Performance of Five-Axis CNC Machine Tool by using the Software-in-the-Loop (SIL) Platform

, 2015
The paper presents the development and implementation of a Software-in-the-loop (SIL) platform allowing the real-time simulation of the hybrid model of five-axis CNC machine tool which is implemented in SIMULINK.
Pislaru, Crinela, Papananias, M., Sztendel, S. +2 more
core

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo +2 more
wiley +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu +2 more
wiley +1 more source

Designing diverse and high-performance proteins with a large language model in the loop. [PDF]

PLoS Comput Biol
Gomez-Uribe CA, Gado J, Islamov M.
europepmc +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source

Differential biventricular responses to VA-ECMO flow ramping after cardiac arrest: establishment of a preclinical ECPR model with PV loop monitoring. [PDF]

Resusc Plus
Owyang CG +14 more
europepmc +1 more source

A model of the Cygnus Loop [PDF]

Monthly Notices of the Royal Astronomical Society, 1982
S. A. E. G. Falle, A. R. Garlick
openaire +1 more source

model-in-the-loop
hardware-in-the-loop
model predictive control

hardware-in-the-loop hil
processor in the loop
software in the loop

hardware-in-the-loop simulation
human-in-the-loop
model-based design