Results 111 to 120 of about 4,793,633 (336)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Model Order Reduction Methods for Rotating Electrical Machines: A Review

Energies
Due to the rise of e-mobility applications, there is an increased demand to create more accurate control methods, which can reduce the loss in an e-drive system.
Kristóf Levente Kiss, Tamás Orosz
doaj   +1 more source

Model order reduction of flow based on a modular geometrical approximation of blood vessels. [PDF]

Comput Methods Appl Mech Eng, 2021
Pegolotti L, Pfaller MR, Marsden AL, Deparis S.   +3 more
europepmc   +1 more source

High‐fidelity large‐signal order reduction approach for composite load model

, 2020
Zixiao Ma, Zhaoyu Wang, Dongbo Zhao, Bai Cui   +3 more
openalex   +2 more sources

Frequency-weighted H2-Pseudo-optimal Model Order Reduction [PDF]

, 2019
Umair Zulfiqar, Victor Sreeram, Mian Ilyas Ahmad, Xin Du   +3 more
openalex   +1 more source

Code, Data and Results for Numerical Experiments in "Structured model order reduction for vibro-acoustic problems using interpolation and balancing methods" [PDF]

, 2022
Quirin Aumann, Steffen W. R. Werner
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Forecast Test for Reducing Dynamical Dimensionality of Model Emulators

Journal of Advances in Modeling Earth Systems
The climate system can be numerically represented by a set of physically based dynamical equations whose solution requires substantial computational resources.
Tongtong Xu, Matthew Newman, Michael A. Alexander, Antonietta Capotondi   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source