Results 121 to 130 of about 35,180,990 (360)

Towards a Two-Dimensional Framework for User Models [PDF]

, 2003
The focus if this paper is user modeling in the context of personalization of information systems. Such a personalization is essential to give users the feeling that the system is easily accessible.
de Vrieze, Paul Ton, Klok, Jakob, van Bommel, Patrick, van der Weide, Theo   +3 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Global atmospheric distribution of microplastics with evidence of low oceanic emissions

npj Climate and Atmospheric Science
Recent investigations based on sea–air transfer physical mechanistic studies suggest that the global ocean’s contribution to atmospheric microplastic emissions is significantly lower (four orders of magnitude) than previously estimated.
Shanye Yang, Guy Brasseur, Stacy Walters, Pablo Lichtig, Cathy W. Y. Li   +4 more
doaj   +1 more source

ellc: A fast, flexible light curve model for detached eclipsing binary stars and transiting exoplanets [PDF]

, 2016
P. F. L. Maxted
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase

Scientific Reports
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites.
Linyue Shang, Huimei Wei, Jing Deng, Madeline J. Stewart, Johnathan E. LeSaint, Annet Kyomuhangi, Shawn Park, Elise C. Maul, Chang-Guo Zhan, Fang Zheng   +9 more
doaj   +1 more source

NON-HERMITIAN QUANTUM DYNAMICS OF A TWO-LEVEL SYSTEM AND MODELS OF DISSIPATIVE ENVIRONMENTS [PDF]

, 2013
ALESSANDRO SERGI, KONSTANTIN G. ZLOSHCHASTIEV   +1 more
openalex   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Discrete Boltzmann trans-scale modeling of high-speed compressible flows [PDF]

, 2018
Yanbiao Gan, Aiguo Xu, Guangcai Zhang, Yudong Zhang, Sauro Succi   +4 more
openalex   +1 more source