Results 51 to 60 of about 2,129,256 (356)

Approximating trigonometric functions by using exponential inequalities

open access: yesJournal of Inequalities and Applications, 2019
In this paper, some exponential inequalities are derived from the inequalities containing trigonometric functions. Numerical examples show that one can achieve much tighter bounds than those of prevailing methods, which are presented by Cusa, Huygens ...
Xiao-Diao Chen, Junyi Ma, Yixin Li
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Cycle Network Model of Prostaglandin H Synthase-1

open access: yesPharmaceuticals, 2020
The kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was developed to investigate its complex network kinetics and non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in different in vitro and in vivo conditions. To correctly describe the complex
Alexey Goltsov   +3 more
doaj   +1 more source

VPMBench: a test bench for variant prioritization methods

open access: yesBMC Bioinformatics, 2021
Background Clinical diagnostics of whole-exome and whole-genome sequencing data requires geneticists to consider thousands of genetic variants for each patient.
Andreas Ruscheinski   +3 more
doaj   +1 more source

Manufacturing Process Modeling and Simulation [PDF]

open access: yes, 2008
This paper presents a methodology to be employed in the whole process design phase including first and second processing. This methodology consists of a set of steps which are characterised by an independent model.
DANTAN, Jean-Yves   +2 more
core   +4 more sources

A Conceptual Approach to Complex Model Management with Generalized Modelling Patterns and Evolutionary Identification

open access: yes, 2018
Complex systems' modeling and simulation are powerful ways to investigate a multitude of natural phenomena providing extended knowledge on their structure and behavior.
Bochenina, Klavdiya O.   +7 more
core   +1 more source

Ecohydraulics Modelling and Simulation [PDF]

open access: yesWater, 2021
Ecohydraulics, the interdiscipline of ecology and hydraulics, has been rapidly developing and receiving ever-growing attention both in hydraulic research efforts and in environmentally oriented professional and lay communities in recent years [...]
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The application of combined momentum and blade element theory for aerodynamics performance analysis of rotating blades [PDF]

open access: yes, 2011
In this thesis, a simulation package for the Six Degrees of Freedom (6DOF ) motion of an underwater vehicle is developed. Mathematical modeling of an underwater vehicle is done and the parameters needed to write such a simulation package are ...
M Mohammed, Abdelrazzak Gumaa
core  

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