Results 61 to 70 of about 2,129,256 (356)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Mathematical modeling of Echinococcosis in humans, dogs and livestock with optimal control strategies [PDF]

Iranian Journal of Numerical Analysis and Optimization
In this paper, we present a deterministic model of Cystic Echinococcosis disease of eleven differential equations, describing complex interactions between three types of hosts, specifically humans, livestock and dogs.
I. Sannaky, M. Riouali, N. Ouldkhouia, I. El berrai, K. Adnaoui   +4 more
doaj   +1 more source

Multiscale Modeling and Simulation of Organic Solar Cells [PDF]

, 2012
In this article, we continue our mathematical study of organic solar cells (OSCs) and propose a two-scale (micro- and macro-scale) model of heterojunction OSCs with interface geometries characterized by an arbitrarily complex morphology.
Bagnis, Bank, Bank, Barker, Beverina, Blom, Braun, Buxton, Caironi, CampbellScott, Carlo de Falco, Casalegno, Coakley, Davis, de Falco, Gatti, Gill, Gunes, Horowitz, Hughes, Jerome, Kimber, Lazarov, Lee, Marsh, Martin, Matteo Porro, Maurizio Verri, Mayer, Mihailetchi, Mingebach, Mori, Morteani, Peumans, Pope, Quarteroni, Ray, Riccardo Sacco, Sharma, Tang, Williams, Xu   +41 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Diffusion of Confidential Information on Networks [PDF]

, 2011
This is a natural generalization of the previous work by Dan, "Modeling and Simulation of Diffusion Phenomena on Social Networks," to appear in The proceedings of 2011 Third International Conference on Computer Modeling and Simulation.
Dan, Yuya
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Dynamics of quantum information resources in two-flavor neutrino oscillations

European Physical Journal C: Particles and Fields
The burgeoning intersection of particle physics and quantum information science unveils significant connections, particularly in the context of neutrinos–fundamental particles that challenge our understanding of mass, mixing, and coherence at the quantum
K. El Bouzaidi, A. Slaoui, L. B. Drissi, E. H. Saidi, R. Ahl Laamara   +4 more
doaj   +1 more source

Automating defects simulation and fault modeling for SRAMs [PDF]

, 2008
The continues improvement in manufacturing process density for very deep sub micron technologies constantly leads to new classes of defects in memory devices. Exploring the effect of fabrication defects in future technologies, and identifying new classes
Al-Ars, Z., Di Carlo, Stefano, Prinetto, Paolo Ernesto, Scionti, A.   +3 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

A multistate platform model for time‐to‐event endpoints in oncology clinical trials

CPT: Pharmacometrics & Systems Pharmacology
A multistate platform model was developed to describe time‐to‐event (TTE) endpoints in an oncology trial through the following states: initial, tumor response (TR), progressive disease (PD), overall survival (OS) event (death), censor to the last ...
Chih‐Wei Lin, Mario Nagase, Sameer Doshi, Sandeep Dutta   +3 more
doaj   +1 more source