Results 71 to 80 of about 4,399,350 (329)
VPMBench: a test bench for variant prioritization methods
BMC Bioinformatics, 2021 Background Clinical diagnostics of whole-exome and whole-genome sequencing data requires geneticists to consider thousands of genetic variants for each patient.
Andreas Ruscheinski +3 more
doaj +1 more source
Summary report of the Simulation Committee [PDF]
, 1977 Topics discussed by the simulation committee included: (1) simulators and their uses; (2) atmospheric disturbance modeling requirements; (3) Status of simulators' capabilities for modeling disturbances; and (4) status of atmospheric disturbance models ...
Kurkowski, R. L.
core +1 more source
Modeling and Simulation in an Educational Context: Teaching and Learning Sciences
Research in Social Sciences and Technology, 2019 In science education, there is a need to evaluate the behavior of dynamic systems. Representing and explaining processes through educational models or simulations enables students to perform activities where it is easier to understand these processes and
C. Brigas
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Minimum Information About a Simulation Experiment (MIASE) [PDF]
, 2011 Reproducibility of experiments is a basic requirement for science. Minimum Information (MI) guidelines have proved a helpful means of enabling reuse of existing work in modern biology. The Minimum Information Required in the Annotation of Models (MIRIAM)
Hucka, Michael, Waltemath, Dagmar
core +3 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Mathematical modeling of Echinococcosis in humans, dogs and livestock with optimal control strategies [PDF]
Iranian Journal of Numerical Analysis and OptimizationIn this paper, we present a deterministic model of Cystic Echinococcosis disease of eleven differential equations, describing complex interactions between three types of hosts, specifically humans, livestock and dogs.
I. Sannaky +4 more
doaj +1 more source
Frontiers in Genetics, 2021 Pancreatic cancer (PaCa) is the seventh most fatal malignancy, with more than 90% mortality rate within the first year of diagnosis. Its treatment can be improved the identification of specific therapeutic targets and their relevant pathways.
Maryum Nisar +7 more
doaj +1 more source
The application of combined momentum and blade element theory for aerodynamics performance analysis of rotating blades [PDF]
, 2011 In this thesis, a simulation package for the Six Degrees of Freedom (6DOF ) motion of an underwater vehicle is developed. Mathematical modeling of an underwater vehicle is done and the parameters needed to write such a simulation package are ...
M Mohammed, Abdelrazzak Gumaa
core
Software that goes with the flow in systems biology [PDF]
, 2010 A recent article in BMC Bioinformatics describes new advances in workflow systems for computational modeling in systems biology. Such systems can accelerate, and improve the consistency of, modeling through automation not only at the simulation and ...
A Funahashi +14 more
core +3 more sources