Results 61 to 70 of about 1,269,111 (343)

Using discrete event simulation (DES) to manage theatre operations in healthcare: An audit-based case study [PDF]

, 2008
This paper discusses the application of Discrete Event Simulation (DES) in modelling the complex relationship between patient types, case-mix and operating theatre allocation in a large National Health Service (NHS) Trust in London.
Gore, J, Komashie, A, Mousavi, A
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri, Mauro Gaggero, Marcello Sanguineti   +2 more
wiley   +1 more source

Shock Reduction through Opposing Jets—Aerodynamic Performance and Flight Stability Perspectives

Applied Sciences, 2019
In this research paper, investigations of counter flow (opposing) jet on the aerodynamic performance, and flight stability characteristics of an airfoil with blunt leading-edge in supersonic regime are performed. Unsteady Reynolds-Averaged Navier-Stokes (
Shagufta Rashid, Fahad Nawaz, Adnan Maqsood, Rizwan Riaz, Shuaib Salamat   +4 more
doaj   +1 more source

Modeling of a non-linear multi-agent distributed control system

Journal of Mechanical Engineering and Sciences, 2022
The present study aims to develop a mathematical model for consensus control system based on Lyapunov Theory and nonlinear dynamics functional equations.
Yong-Chai Tan, Jer-Vui Lee, Vin-Cent Tai, Li-Siang Ngow, Long Tan   +4 more
doaj   +1 more source

Potential applications of simulation modelling techniques in healthcare: lessons learned from aerospace and military [PDF]

, 2008
The Aerospace and Military areas are to do with complex missions and situations. Modelling and Simulation (M&S) has been applied in many areas of defence ranging from space sciences, satellite engineering to multi-warfare (air warfare, undersea warfare),
Eldabi, T, Jahangirian, M, Stergioulas, LK   +2 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Predicting motor policy loss – a ZAIG model or a two stage neural network approach? [PDF]

, 2019
Artificial neural networks have increasingly being applied to solve problems which traditionally would have fallen under the domain of more classical statistical methodology, and the latter has long been a staple of popular actuarial methodology.
Aarohi, Luke, European Simulation and Modelling Conference 2019 (ESM'2019), Suda, David   +2 more
core  

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source