Improving translational studies: lessons from rare neuromuscular diseases [PDF]
, 2015 Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
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Ecotoxicology and Environmental SafetyLambda-Cyhalothrin (LCT), a potent insecticide, is renowned for its efficacy, rapid onset, and broad-spectrum insecticidal activity. With rising annual demand for LCT, environmental concerns have similarly intensified.
Xiu-wen Yuan +7 more
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Quality of Reporting and Adherence to ARRIVE Guidelines in Animal Studies for Chagas Disease Preclinical Drug Research: A Systematic Review [PDF]
, 2015 Publication of accurate and detailed descriptions of methods in research articles involving animals is essential for health scientists to accurately interpret published data, evaluate results and replicate findings. Inadequate reporting of key aspects of
García Bournissen, Facundo +2 more
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Scientific ReportsIn laboratory animals, there is a scarcity of digestibility data under non-experimental conditions. Such data is important as basis to generate nutrient requirements, which contributes to the refinement of husbandry conditions.
Linda F. Böswald +2 more
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AnimalsPolystyrene microplastics (PS-MPs) are microplastic particles produced during plastic manufacturing and environmental degradation, accumulating over time and entering ecosystems through various pathways, ultimately affecting organisms and inducing toxic ...
Hui-Mei Huang +7 more
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Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]
, 2018 The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski +11 more
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Cepharanthine hydrochloride: a novel ferroptosis-inducing agent for prostate cancer treatment
Frontiers in PharmacologyBackgroundFerroptosis is an intracellular iron-dependent cell death that is distinct from apoptosis, necrosis, and autophagy. Increasing evidence indicated that ferroptosis plays a crucial role in suppressing tumors, thus providing new opportunities for ...
Jing-Song Guan +9 more
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Flexible and practical modeling of animal telemetry data: hidden Markov models and extensions [PDF]
, 2012 We discuss hidden Markov-type models for fitting a variety of multistate random walks to wildlife movement data. Discrete-time hidden Markov models (HMMs) achieve considerable computational gains by focusing on observations that are regularly spaced in ...
Langrock, R. +5 more
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Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells
Journal of Experimental & Clinical Cancer Research, 2019 Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
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Microfluidics : the fur-free way towards personalised medicine in cancer therapy [PDF]
, 2016 Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients.
Bower, Ruth +3 more
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