Results 1 to 10 of about 1,977,773 (318)

Interactions between DC-SIGN and the envelope protein from Dengue and Zika viruses: a structural perspective based on molecular dynamics and MM/GBSA analyses

Virology Journal, 2023
Zika virus (ZIKV) and dengue virus (DENV) share a lot of similarities being both phylogenetically closely related, share the same insect vector passage for reaching the host, affinity for the same carbohydrate receptor domains (CRDs), indicating feasible
Bruno Stein Barbosa Menechino, Rodrigo Bentes Kato, Helena Cristina Ferreira Franz, Pedro Eduardo Almeida da Silva, Marcus Corat, Daniel Ferreira de Lima Neto   +5 more
doaj   +1 more source

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling

Frontiers in Immunology, 2023
Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that acts as a negative regulator in the immune system and bone metabolism.
Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura   +5 more
doaj   +1 more source

Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice

Frontiers in Aging Neuroscience
BackgroundBidirectional communication and mutual regulation between the gastrointestinal tract and the CNS is facilitated through the gut-brain axis. Recent studies have found reduced diversity of the gut microbiota in Alzheimer’s disease (AD) patients ...
Arnas Kunevičius, Akshay Kumar Vijaya, Alessandro Atzeni, Jonas Mingaila, Ieva Šimoliūnė, Rapolas Jamontas, Emilija Keževičiūtė, Miguel Gueimonde, Rolandas Meškys, Daiva Baltriukienė, Silvia Arboleya, Aurelijus Burokas   +11 more
doaj   +1 more source

At the Biological Modeling and Simulation Frontier [PDF]

Pharmaceutical Research, 2009
We provide a rationale for and describe examples of synthetic modeling and simulation (M&S) of biological systems. We explain how synthetic methods are distinct from familiar inductive methods. Synthetic M&S is a means to better understand the mechanisms that generate normal and disease-related phenomena observed in research, and how compounds of ...
Hunt, C. Anthony, Ropella, Glen E., Lam, Tai Ning, Tang, Jonathan, Kim, Sean H., Engelberg, Jesse A., Sheikh-Bahaei, Shahab   +6 more
openaire   +4 more sources

Parasites as biological models

Parasitology, 1969
The value of metazoan parasites as models for the investigation of fundamental biological phenomena is discussed. The fields in which they are of particular value include: immunology, neuromuscular physiology, nucleo-cytoplasmic relationships, genetics, cyto-differentiation, comparative biochemistry.After reviewing some examples of experimental ...
openaire   +2 more sources

Sodium benzoate may reduce appetite in Drosophila melanogaster through serotonin upregulation [PDF]

Archives of Biological Sciences
Sodium benzoate is a common artificial preservative in processed food, yet little is known about its long-term health effects. Since sodium benzoate could upregulate serotonin, we hypothesized that it may induce satiety and activate processes underlying ...
Nas John Sylvester B., Medina Paul Mark B.   +1 more
doaj   +1 more source

The lees extracts of Philippine rice wine (Tapuy) protect transgenic Caenorhabditis elegans from glyphosate-induced neurotoxicity

Food Production, Processing and Nutrition
Tapuy is an indigenous rice wine traditionally prepared during rituals and ceremonies in the northern regions of the Philippines. Its fermentation by-product, the Tapuy lees, is nutrient-dense but is underutilized for human consumption.
Junelle Rey C. Bacong, Mark Joseph R. Remucal, Paul Mark B. Medina   +2 more
doaj   +1 more source

Peptimapper: proteogenomics workflow for the expert annotation of eukaryotic genomes

BMC Genomics, 2019
Background Accurate structural annotation of genomes is still a challenge, despite the progress made over the past decade. The prediction of gene structure remains difficult, especially for eukaryotic species, and is often erroneous and incomplete.
Laetitia Guillot, Ludovic Delage, Alain Viari, Yves Vandenbrouck, Emmanuelle Com, Andrés Ritter, Régis Lavigne, Dominique Marie, Pierre Peterlongo, Philippe Potin, Charles Pineau   +10 more
doaj   +1 more source

Neurotoxic and neuromotor effects of cyanate, an oxidative byproduct of cyanide from linamarin in cassava: A systematic review

NAJFNR
Background Linamarin-induced neurotoxicity manifests as either polyneuropathy, ataxia, and sensorineural deafness or as isolated symmetric spastic paraparesis of bilateral limbs, which are frequently observed in populations subsisting on a monotonous ...
Rafael Vincent Manalo, Antonio Lorenzo Ong, Paul Mark Medina   +2 more
doaj   +1 more source