Results 31 to 40 of about 3,734,088 (300)

Decoding Sequence Classification Models for Acquiring New Biological Insights [PDF]

, 2010
Classifying biological sequences is one of the most important tasks in computational biology. In the last decade, support vector machines (SVMs) in combination with sequence kernels have emerged as a de-facto standard.
Andreas Kothmeier, Carsten Mahrenholz, Ingrid Abfalter, Sepp Hochreiter, Ulrich Bodenhofer, Ulrich Bodenhofer   +5 more
core   +2 more sources

Using mechanistic animal growth models to estimate genetic parameters of biological traits [PDF]

, 2007
Mechanistic animal growth models can incorporate a description of the genotype as represented by underlying biological traits that aim to specify the animal's genetic potential for performance, independent from the environmental factors captured by the ...
A.B. Doeschl-Wilson, B.P. Kinghorn, Blasco, Cameron, Chang, De Vries, Emmans, Emmans, Ferguson, Ferguson, Fernandez, Fowler, Glazier, Gous, Groeneveld, H.A.M. Van der Steen, Kirkpatrick, Knap, Knap, Knap, Knap, Knap, Knap, Ma Chang-Xing, Mayer, McKay, Moughan, P.W. Knap, Storn, Tarantola, Taylor, Varona, Varona, Whittemore, Whittemore, Wood   +35 more
core   +2 more sources

Interactions between DC-SIGN and the envelope protein from Dengue and Zika viruses: a structural perspective based on molecular dynamics and MM/GBSA analyses

Virology Journal, 2023
Zika virus (ZIKV) and dengue virus (DENV) share a lot of similarities being both phylogenetically closely related, share the same insect vector passage for reaching the host, affinity for the same carbohydrate receptor domains (CRDs), indicating feasible
Bruno Stein Barbosa Menechino, Rodrigo Bentes Kato, Helena Cristina Ferreira Franz, Pedro Eduardo Almeida da Silva, Marcus Corat, Daniel Ferreira de Lima Neto   +5 more
doaj   +1 more source

Relaxation kinetics of biological dimer adsorption models

, 2001
We discuss the relaxation kinetics of a one-dimensional dimer adsorption model as recently proposed for the binding of biological dimers like kinesin on microtubules.
, , , A Vilfan, Bares P.-A., E Frey, F Schwabl, Hoenger A., Page E. S., Privman V. (ed), Privman V. andm Nielaba P., Schütz G.   +11 more
core   +1 more source

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

DCIR suppresses osteoclastic proliferation and resorption by downregulating M-CSF and RANKL signaling

Frontiers in Immunology, 2023
Dendritic cell immunoreceptor (DCIR) is an inhibitory C-type lectin receptor that acts as a negative regulator in the immune system and bone metabolism.
Tomonori Kaifu, Takumi Maruhashi, Soo-Hyun Chung, Kenji Shimizu, Akira Nakamura, Yoichiro Iwakura   +5 more
doaj   +1 more source

Mechanochemical models for generating biological pattern and form in development [PDF]

, 1988
The central issue in development is the formation of spatial patterns of cells in the early embryo. The mechanisms which generate these patterns are unknown.
Maini, P. K., Murray, J. D., Tranquillo, R. T.   +2 more
core   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid profiles in mice

Frontiers in Aging Neuroscience
BackgroundBidirectional communication and mutual regulation between the gastrointestinal tract and the CNS is facilitated through the gut-brain axis. Recent studies have found reduced diversity of the gut microbiota in Alzheimer’s disease (AD) patients ...
Arnas Kunevičius, Akshay Kumar Vijaya, Alessandro Atzeni, Jonas Mingaila, Ieva Šimoliūnė, Rapolas Jamontas, Emilija Keževičiūtė, Miguel Gueimonde, Rolandas Meškys, Daiva Baltriukienė, Silvia Arboleya, Aurelijus Burokas   +11 more
doaj   +1 more source

Modelling Coordination in Biological Systems [PDF]

, 2006
We present an application of the Reo coordination paradigm to provide a compositional formal model for describing and reasoning about the behaviour of biological systems, such as regulatory gene networks. Reo governs the interaction and flow of data between components by allowing the construction of connector circuits which have a precise formal ...
Clarke, Dave, Costa, David, Arbab, Farhad   +2 more
openaire   +1 more source