Results 91 to 100 of about 24,835,738 (277)

Effects of starter cultures on the metabolite profile, antioxidant activities, and anti-aging properties of tapuy lees

Discover Food
The Philippine rice wine (tapuy) and tapuy lees making process utilizes bubod, the traditional starter culture. The bubod contains variable number and species of microorganisms and influences the physical and chemical properties of tapuy and tapuy lees ...
Edward Kevin B. Bragais, Paul Mark B. Medina   +1 more
doaj   +1 more source

Epithelial–mesenchymal transition (EMT) and its role in acquired epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) chemoresistance in non-small cell lung cancer (NSCLC)

Cancer Pathogenesis and Therapy
Epithelial–mesenchymal transition (EMT) is a biological process that involves the transformation of epithelial cells into cells with a mesenchymal phenotype, enhancing their migratory and invasive capabilities.
Ma. Carmela P. Dela Cruz, Paul Mark B. Medina   +1 more
doaj   +1 more source

Correction to: Rapid turnover of life-cycle-related genes in the brown algae

Genome Biology, 2019
Following publication of the original article [1], it was noticed that the author names were published with initials instead of full names. The article [1] has been updated.
Agnieszka P. Lipinska, Martha L. Serrano-Serrano, Alexandre Cormier, Akira F. Peters, Kazuhiro Kogame, J. Mark Cock, Susana M. Coelho   +6 more
doaj   +1 more source

Probabilistic models of biological enzymatic polymerization.

PLoS ONE, 2021
In this study, hierarchies of probabilistic models are evaluated for their ability to characterize the untemplated addition of adenine and uracil to the 3' ends of mitochondrial mRNAs of the human pathogen Trypanosoma brucei, and for their generative ...
Marshall Hampton, Miranda Galey, Clara Smoniewski, Sara L Zimmer   +3 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The coefficient of determination R2 and intra-class correlation coefficient from generalized linear mixed-effects models revisited and expanded

bioRxiv, 2016
The coefficient of determination R2 quantifies the proportion of variance explained by a statistical model and is an important summary statistic of biological interest.
S Nakagawa, P. C. Johnson, H. Schielzeth
semanticscholar   +1 more source

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Nature Communications, 2022
Mutations that enhance the activity of protein kinase C alpha (PKCα) are associated with Alzheimer’s Disease. Here, the authors report that the enhanced activity of one variant, PKCα M489V, is sufficient to rewire the brain phosphoproteome, drive ...
Gema Lordén, Jacob M. Wozniak, Kim Doré, Lara E. Dozier, Chelsea Cates-Gatto, Gentry N. Patrick, David J. Gonzalez, Amanda J. Roberts, Rudolph E. Tanzi, Alexandra C. Newton   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

'Towards a Conceptual Framework for Innate Immunity' [PDF]

, 2005
Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Twycross, Jamie
core   +3 more sources

Robust and efficient parameter estimation in dynamic models of biological systems

BMC Systems Biology, 2015
BackgroundDynamic modelling provides a systematic framework to understand function in biological systems. Parameter estimation in nonlinear dynamic models remains a very challenging inverse problem due to its nonconvexity and ill-conditioning. Associated
A. Gábor, J. Banga
semanticscholar   +1 more source