Results 21 to 30 of about 3,547,769 (181)
Pharmaceutical Biology, 2020 Context L-DOPA is the first-line drug for Parkinson’s disease (PD). However, chronic use can lead to dyskinesia. Caffeine, which is a known neuroprotectant, can potentially act as an adjunct to minimise adverse effects of L-DOPA.
Rafael Vincent M. Manalo +1 more
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The Effect of a Unique Region of Parvovirus B19 Capsid Protein VP1 on Endothelial Cells
Biomolecules, 2021 Parvovirus B19 (B19V) is a widespread human pathogen possessing a high tropism for erythroid precursor cells. However, the persistence or active replication of B19V in endothelial cells (EC) has been detected in diverse human pathologies.
Ieva Rinkūnaitė +6 more
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Setting Parameters for Biological Models With ANIMO [PDF]
, 2014 ANIMO (Analysis of Networks with Interactive MOdeling) is a software for modeling biological networks, such as e.g. signaling, metabolic or gene networks. An ANIMO model is essentially the sum of a network topology and a number of interaction parameters.
Karperien, Marcel +5 more
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At the Biological Modeling and Simulation Frontier [PDF]
Pharmaceutical Research, 2009 We provide a rationale for and describe examples of synthetic modeling and simulation (M&S) of biological systems. We explain how synthetic methods are distinct from familiar inductive methods. Synthetic M&S is a means to better understand the mechanisms that generate normal and disease-related phenomena observed in research, and how compounds of ...
C. Anthony Hunt +7 more
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Frontiers in Pharmacology, 2021 Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from Aconitum plants, is widely used in traditional herbal medicine to treat various diseases.
Qing Xia +26 more
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Of (Biological) Models and Simulations [PDF]
MOJ Proteomics & Bioinformatics, 2016 Modeling and simulation are recognized as important aspects of the scientific method for more than 70 years but its adoption in biology has been slow. Debates on its representativeness, usefulness, and whether the effort spent on such endeavors is worthwhile, exist to this day.
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Internal Models in Biological Control [PDF]
Annual Review of Control, Robotics, and Autonomous Systems, 2019 Rationality principles such as optimal feedback control and Bayesian inference underpin a probabilistic framework that has accounted for a range of empirical phenomena in biological sensorimotor control. To facilitate the optimization of flexible and robust behaviors consistent with these theories, the ability to construct internal models of the motor ...
Daniel McNamee +3 more
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Generic model for biological regulation [PDF]
F1000Research, 2022 Abstract Substantial portion of molecules in an organism is involved in regulation of a wide spectrum of biological processes. Several models have been presented for various forms of biological regulation, including gene expression regulation and physiological regulation; however, a generic model is missing.
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Development and validation of computational models of cellular interaction [PDF]
, 2004 In this paper we take the view that computational models of biological systems should satisfy two conditions – they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be ...
Holcombe, W.M.L. +2 more
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Duplication Models for Biological Networks [PDF]
Journal of Computational Biology, 2003 Are biological networks different from other large complex networks? Both large biological and non-biological networks exhibit power-law graphs (number of nodes with degree k, N(k) ~ k-b) yet the exponents, b, fall into different ranges. This may be because duplication of the information in the genome is a dominant evolutionary force in shaping ...
Linyuan Lu +3 more
openaire +4 more sources