Research Models for Studying Vascular Calcification [PDF]
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen+4 more
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Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. [PDF]
BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events.
Blaha, Michael J+7 more
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Modelling the cardiovascular system
Cardiovascular disease claims more lives than any other disease in westernised countries, affecting millions. Pinpointing cardiovascular system dysfunction is often difficult because the clinical signs, or the availability and interpretation of physiological measurements, are unreliable. Often patient-specific information is incomplete or confusing, as
Geoffrey M, Shaw+6 more
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Modelling the cardiovascular effects of ephedrine [PDF]
Aims Recent reports have called into question the safety of ephedra supplements especially with regards to their cardiovascular effects. The purpose of this analysis was to characterize, via pharmacokinetic/pharmacodynamic modelling, the cardiovascular effects of ephedrine, the main active ingredient of ephedra, in apparently healthy, overweight ...
Adam M. Persky+3 more
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Outflow boundary conditions for 3D simulations of non-periodic blood flow and pressure fields in deformable arteries [PDF]
The simulation of blood flow and pressure in arteries requires outflow boundary conditions that incorporate models of downstream domains. We previously described a coupled multidomain method to couple analytical models of the downstream domains with 3D ...
Figueroa, C. A.+3 more
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Epigenomes in Cardiovascular Disease. [PDF]
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA+4 more
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A Kerala model for cardiovascular research?
India's contribution to cardiovascular research has been dismal with a share of only 1% of total number of papers published in the world during the period 1999-2008. Based on two recent studies published from Kerala, the Kerala ACS Registry and the CSI Kerala CRP Study and four other studies being undertaken in Kerala, we think that a Kerala model for ...
Krishnan Mangalath Narayanan+2 more
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Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art [PDF]
Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits.
PAGLIARO, BENIAMINO ROSARIO+3 more
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The genetics of cardiovascular disease [PDF]
Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models,
Abu-Amero+72 more
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Non-invasive evaluation of left ventricular afterload, part 2 : arterial pressure-flow and pressure-volume relations in humans [PDF]
The mechanical load imposed by the systemic circulation to the left ventricle is an important determinant of normal and abnormal cardiovascular function.
Chirinos Medina, Julio, Segers, Patrick
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