Results 21 to 30 of about 1,317,332 (190)

Modelling the cardiovascular system

Critical Care and Resuscitation, 2007
Cardiovascular disease claims more lives than any other disease in westernised countries, affecting millions. Pinpointing cardiovascular system dysfunction is often difficult because the clinical signs, or the availability and interpretation of physiological measurements, are unreliable. Often patient-specific information is incomplete or confusing, as
Shaw, G. M., Chase, J. G., Starfinger, C., Smith, B., Hann, C. E., Desaive, Thomas, Ghuysen, Alexandre   +6 more
openaire   +3 more sources

Human Cell Modeling for Cardiovascular Diseases [PDF]

International Journal of Molecular Sciences, 2020
The availability of appropriate and reliable in vitro cell models recapitulating human cardiovascular diseases has been the aim of numerous researchers, in order to retrace pathologic phenotypes, elucidate molecular mechanisms, and discover therapies using simple and reproducible techniques.
Lippi M., Stadiotti I., Pompilio G., Sommariva E.   +3 more
openaire   +2 more sources

Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts

Animal Models and Experimental Medicine, 2021
Heart transplantation is a lifesaving procedure, which is limited by the availability of donor hearts. Using hearts from donors after circulatory death, which have sustained global ischemia, requires thorough studies on reliable and reproducible models ...
Mohammed Quader, Renee Cholyway, Niluka Wickramaratne, Oluwatoyin Akande, Martin Mangino, Eleonora Mezzaroma, Adolfo G. Mauro, Qun Chen, Alexander Kantlis, Stefano Toldo   +9 more
doaj   +1 more source

Phytochemical Compounds and Protection from Cardiovascular Diseasesa. A State of the Art [PDF]

, 2015
Cardiovascular diseases represent a worldwide relevant socioeconomical problem. Cardiovascular disease prevention relies also on lifestyle changes, including dietary habits.
PAGLIARO, BENIAMINO ROSARIO, RUBATTU, Speranza Donatella, SANTOLAMAZZA, CATERINA, SIMONELLI, FRANCESCA   +3 more
core   +4 more sources

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Journal of Lipid Research, 2009
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is predominantly expressed in liver and regulates cholesterol metabolism by down regulating liver LDL receptor (LDLR) proteins.
Yi Luo, Laurie Warren, Donghui Xia, Heather Jensen, Thomas Sand, Stephen Petras, Wenning Qin, Kenneth S. Miller, Julie Hawkins   +8 more
doaj   +1 more source

Animal Models of Cardiovascular Diseases [PDF]

BioMed Research International, 2011
Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos, Gomez-Guerrero, Carmen, Martin-Ventura, Jose Luis, Blanco-Colio, Luis, Lavín Plaza, Begoña, Mallavia, Beñat, Tarin, Carlos, Mas, Sebastian, Ortiz, Alberto, Egido, Jesus   +9 more
openaire   +3 more sources

Creating Fair Models of Atherosclerotic Cardiovascular Disease Risk [PDF]

, 2019
Guidelines for the management of atherosclerotic cardiovascular disease (ASCVD) recommend the use of risk stratification models to identify patients most likely to benefit from cholesterol-lowering and other therapies.
Coulet, Adrien, Marafino, Ben, Palaniappan, Latha, Pfohl, Stephen, Rodriguez, Fatima, Shah, Nigam H.   +5 more
core   +4 more sources

Plasma lipidomic signatures of spontaneous obese rhesus monkeys

Lipids in Health and Disease, 2019
Background Obesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D).
Junlong Wang, Linqiang Zhang, Ruyue Xiao, Yunhai Li, Shasha Liao, Zhiguo Zhang, Wenhui Yang, Bin Liang   +7 more
doaj   +1 more source

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Frontiers in Cell and Developmental Biology, 2020
RNA modifications have emerged as key regulators of transcript expression in diverse physiological and pathological processes. As one of the most prevalent types of RNA modifications, N6-methyladenosine (m6A) has become the highlight in modulation of ...
Wenchao Zhang, Wenchao Zhang, Lile He, Lile He, Zhongyue Liu, Zhongyue Liu, Xiaolei Ren, Xiaolei Ren, Lin Qi, Lin Qi, Lu Wan, Lu Wan, Wanchun Wang, Wanchun Wang, Chao Tu, Chao Tu, Zhihong Li, Zhihong Li   +17 more
doaj   +1 more source

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Frontiers in Molecular Biosciences, 2019
Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health–related proteins have
Lile He, Lile He, Xiangyu Shi, Ruiqi Chen, Ruiqi Chen, Zhengchun Wu, Zhulin Yang, Zhihong Li, Zhihong Li   +8 more
doaj   +1 more source