Results 91 to 100 of about 1,158,124 (312)

Preliminary evaluation of the neuroprotective activity of Cannabidiol in combination with some current medicinal drugs in vitro

Revista Mexicana de Neurociencia
Objective: The objective of this study was to evaluate the neurotoxicity and neuroprotective activity of cannabidiol (CBD), valproate, furosemide, metformin, and bilobalide, individually and mixed with CBD in PC12 cells exposed to Glutamate. In addition,
Jesús Vélez-Huerta, Eder U. Arredondo-Espinoza, Karla Ramírez-Estrada, Mónica A. Ramírez-Cabrera, Omar González-Santiago   +4 more
doaj  

Fine-tuning Large Language Models for Chemical Text Mining

Extracting knowledge from complex and diverse chemical texts is a pivotal task for both experimental and computational chemists. The task is still considered to be extremely challenging due to the complexity of the chemical language and scientific ...
Yitian, Wang, Duanhua, Cao, Runze, Zhang, Qinggong, Wang, Buying, Niu, Mingan, Chen, Ziming, Huang, Lehan, Zhang, Xutong, Li, Qian, Shi, Shengkun, Ni, Zunyun, Fu, Jiacheng, Xiong, Mingyue, Zheng, Zhaoping, Xiong, Xiangtai, Kong, Wei, Zhang   +16 more
core   +1 more source

Information extraction from chemical patents

, 2011
The automated extraction of semantic chemical data from the existing literature is demonstrated. For reasons of copyright, the work is focused on the patent literature, though the methods are expected to apply equally to other areas of the chemical ...

core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Representations and strategies for transferable machine learning improve model performance in chemical discovery

, 2022
Strategies for machine-learning(ML)-accelerated discovery that are general across materials composition spaces are essential, but demonstrations of ML have been primarily limited to narrow composition variations.
Heather J. Kulik, Arunachalam, Naveen, Janet, Jon Paul, Aditya Nandy, Daniel R. Harper, Duan, Chenru, Jon Paul Janet, Nandy, Aditya, Kulik, Heather J, Harper, Daniel R, Naveen Arunachalam, Chenru Duan   +11 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Microscopic Models for Chemical Thermodynamics [PDF]

Journal of Statistical Physics, 2005
We introduce an infinite particle system dynamics, which includes stochastic chemical kinetics models, the classical Kac model and free space movement. We study energy redistribution between two energy types (kinetic and chemical) in different time scales, similar to energy redistribution in the living cell.
openaire   +2 more sources

HDAC6 and TDP-43 promote autophagy impairment in amyotrophic lateral sclerosis

Neurobiology of Disease
TDP-43 is known to bind the mRNA of histone deacetylase 6 (HDAC6), influencing its RNA translation. Many studies suggest that HDAC6 participates in the regulation of autophagy, which we found impaired in sporadic amyotrophic lateral sclerosis (sALS ...
Matteo Bordoni, Eveljn Scarian, Emanuela Jacchetti, Camilla Viola, Luca Diamanti, Francesca Dragoni, Rosalinda Di Gerlando, Bartolo Rizzo, Manuela Teresa Raimondi, Stella Gagliardi, Orietta Pansarasa   +10 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source