Results 81 to 90 of about 2,739,180 (294)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Chemo-spectrophotometric evolution of spiral galaxies: III. Abundance and colour gradients in discs
, 1999 We study the relations between luminosity and chemical abundance profiles of spiral galaxies, using detailed models for the chemical and spectro-photometric evolution of galactic discs.
Boissier, S., Prantzos, N.
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
HDAC6 and TDP-43 promote autophagy impairment in amyotrophic lateral sclerosis
Neurobiology of DiseaseTDP-43 is known to bind the mRNA of histone deacetylase 6 (HDAC6), influencing its RNA translation. Many studies suggest that HDAC6 participates in the regulation of autophagy, which we found impaired in sporadic amyotrophic lateral sclerosis (sALS ...
Matteo Bordoni +10 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Impact parameter dependencies in Pb(160 AGeV)+Pb reactions : hydrodynamical vs. cascade calculations [PDF]
, 2005 We investigate the impact parameter dependence of the specific entropy S/A in relativistic heavy ion collisions. Especially the anti-Lambda/anti-proton ratio is found to be a useful tool to distinguish between chemical equilibrium assumptions assumed in ...
Bleicher, Marcus +6 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
OPTIMIZATION OF PRETREATMENT CONDITIONS OF CARROTS TO MAXIMIZE JUICE RECOVERY BY RESPONSE SURFACE METHODOLOGY [PDF]
Journal of Engineering Science and Technology, 2006 Carrot juice was expressed in a hydraulic press using a wooden set up. Carrot samples pretreated at different designed combinations, using Central Composite Rotatable Design (CCRD), Response Surface Methodology (RSM), of pH, temperature and time were ...
H. K. SHARMA +4 more
doaj