Results 61 to 70 of about 25,447,146 (290)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Potential role of senescent macrophages in radiation-induced pulmonary fibrosis
Cell Death and Disease, 2021 Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic with poor prognosis and limited therapeutic options. Previous results have shown that senescent cells, such as fibroblast and type II airway epithelial cell,
Lulu Su +10 more
doaj +1 more source
FEBS Letters, EarlyView.Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii +8 more
wiley +1 more source
Fréchet ChemNet Distance: A Metric for Generative Models for Molecules in Drug Discovery [PDF]
Journal of Chemical Information and Modeling, 2018 The new wave of successful generative models in machine learning has increased the interest in deep learning driven de novo drug design. However, method comparison is difficult because of various flaws of the currently employed evaluation metrics.
Kristina Preuer +4 more
semanticscholar +1 more source
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
FEBS Letters, EarlyView.Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera +4 more
wiley +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Chemical Process Modeling in Modelica [PDF]
Linköping Electronic Conference Proceedings, 2012 Chemical process models are highly structured. Information on how the hierarchical components are connected helps to solve the model efficiently. The structural information retrieved from the JModelica environment will play an important role in the development of our novel optimization methods.
Baharev, Ali, Neumaier, Arnold
openaire +2 more sources
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
SET-THEORETIC DESCRITPION OF FUNCTIONAL MODELS OF CHEMICAL MANUFACTURING
Тонкие химические технологии, 2017 The technique for the formalized description of functional models of chemical manufacturing is developed. The technique is based on graph theory.
E. V. Burlyaeva +2 more
doaj +1 more source
On the concept of a chemical model
Croatica chemica acta, 1997 The concepts of model and modeling are discussed. Various classifications of models are given. It is pointed out that the progress of science in general and chemistry in particular is based on models and modeling since no better tools have yet been found to study Nature.
Nikolić, Sonja, Trinajstić, Nenad
openaire +2 more sources