Results 71 to 80 of about 3,531,989 (315)

Quasiparticle Model of Quark-Gluon Plasma at Imaginary Chemical Potential [PDF]

open access: yesPhys.Rev.D77:034004,2008, 2007
A quasiparticle model of the quark-gluon plasma is compared with lattice QCD data for purely imaginary chemical potential. Net quark number density, susceptibility as well as the deconfinement border line in the phase diagram of strongly interacting matter are investigated.
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Qualitative Theory and Chemical Explanation [PDF]

open access: yes, 2002
Roald Hoffmann and other theorists claim that we we ought to use highly idealized chemical models (``qualitative models'') in order to increase our understanding of chemical phenomena, even though other models are available which make more highly ...
Weisberg, Michael
core  

A linguagem química e o ensino da química orgânica Chemical language and organic chemistry chemistry teaching

open access: yesQuímica Nova, 2008
The importance of chemical language and specifically of molecular models and their representations in the development of chemistry is discussed. Structural formulas are projections of molecular models used as a specific language by chemists.
Nídia Franca Roque   +1 more
doaj   +1 more source

Thermodynamically predicted oscillations in closed chemical systems [PDF]

open access: yesarXiv, 2010
All known up to now models of chemical oscillations are based exclusively on kinetic considerations. The chemical gross-process equation is split usually by elementary steps, each step is supplied by an arrow and a differential equation, joint solution to such a construction under certain, often ad hoc chosen conditions and with ad hoc numerical ...
arxiv  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

open access: yesFEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti   +3 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Exploring chemical space — Generative models and their evaluation

open access: yesArtificial Intelligence in the Life Sciences, 2023
Recent advances in the field of artificial intelligence, specifically regarding deep learning methods, have invigorated research into novel ways for the exploration of chemical space.
Martin Vogt
doaj  

Home - About - Disclaimer - Privacy