Results 71 to 80 of about 2,719,550 (270)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Dynamical strategies for obstacle avoidance during Dictyostelium discoideum aggregation: a Multi-agent system model [PDF]

, 2019
Chemotaxis, the movement of an organism in response to chemical stimuli, is a typical feature of many microbiological systems. In particular, the social amoeba \textit{Disctyostelium discoideum} is widely used as a model organism, but it is not still ...
Maggiora, Marco, Proverbio, Daniele
core   +1 more source

Origin of chemical and dynamical properties of the Galactic thick disk

, 2011
We adopt a scenario in which the Galactic thick disk was formed by minor merging between the first generation of the Galactic thin disk (FGTD) and a dwarf galaxy about 9 Gyr ago and thereby investigate chemical and dynamical properties of the Galactic ...
Abadi, Allende Prieto, Bekki, Bekki, Bekki, Bensby, Binney, Binney, Brook, Carollo, Chiappini, Chiba, Dierickx, Dinescu, Edvardsson, Frogel, Fuhrmann, Gilmore, Gilmore, Gratton, Huang, Humphreys, Ivezić, Jurić, Karataş, Kazantzidis, Kenji Bekki, Larsen, Larsen, Lee, Loebman, Parker, Prochaska, Reddy, Reddy, Robin, Roškar, Ruchti, Takuji Tsujimoto, Tsujimoto, Tsujimoto, Villalobos, Yoachim, Yoshii   +43 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Construção de modelos para ilustração de estruturas moleculares em aulas de química

Química Nova, 1999
This paper describes the construction of a kit of molecular model for illustration of molecular structure in chemical class using cheap materials. The atoms were represented by plastic spheres and the bonds between the atoms were made from plastic straws
Lima M. B., Lima-Neto P. De
doaj  

Mathematical modeling for digestible protein in animal feeds for tilapia

Revista Brasileira de Zootecnia, 2012
The objective of this study was to formulate mathematical models to estimate digestible protein in some animal feeds for tilapia. Literature results of the proximate composition of crude protein, ether extract, and mineral matter, as well as digestible ...
Luiz Vítor Oliveira Vidal, Wilson Massamitu Furuya, Elias Nunes Martins, Tadeu Orlandi Xavier, Mariana Michelato, Themis Sakaguti Graciano   +5 more
doaj   +1 more source

Loose mechanochemical coupling of molecular motors

, 2011
In living cells, molecular motors convert chemical energy into mechanical work. Its thermodynamic energy efficiency, i.e. the ratio of output mechanical work to input chemical energy, is usually high.
Howard J., Oster G., Wang H., Yasuda R., YUNXIN ZHANG   +4 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source