Results 121 to 130 of about 25,171,962 (340)
Genetic models of human and mouse dendritic cell development and function
Nature reviews. Immunology, 2020 David A Anderson +3 more
semanticscholar +1 more source
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Chromosome-level genome assembly of a destructive leaf-mining moth Eriocrania semipurpurella alpina
Scientific DataEriocraniidae (Lepidoptera) are widespread leaf miners and have unique adaptability to hypoxia and low temperatures, causing covert but devastating harm to Fagales (Betulaceae and Fagaceae) plants in the Holarctic.
Gui-fang Wang +7 more
doaj +1 more source
Case Reports in Genetics, 2014 Autism spectrum disorder (ASD) is a highly heritable disease (~0.9) with a complex genetic etiology. It is initially characterized by altered cognitive ability which commonly includes impaired language and communication skills as well as fundamental ...
Marina Laplana +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates
Genome Biology, 2019 Background Brain aging is a complex process that depends on the precise regulation of multiple brain regions; however, the underlying molecular mechanisms behind this process remain to be clarified in non-human primates.
Ming-Li Li +9 more
doaj +1 more source
Four new bat species from the Gaoligong Mountain and an updated catalogue of bats in China
Global Ecology and ConservationThe Gaoligong Mountain (GLGM), situated at the border of Myanmar and southwestern China, encompasses three globally significant biodiversity hotspots. To assess its bat diversity, we undertook two consecutive years of surveys utilizing newly collected ...
Rongsong Luo, Mengcheng Li, Zhen Liu
doaj
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Immunity & AgeingBackground Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. Despite receiving HAART, immune reconstitution is not fully optimized.
Na Li +9 more
doaj +1 more source