Results 61 to 70 of about 2,634,573 (271)

Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation

BMC Biology
Background The tree shrew (Tupaia belangeri) is a promising emerging model organism in biomedical studies, notably due to their evolutionary proximity to primates.
Dongmin R. Son, Yifan Kong, Yulian Tan, Ting Hu, Lei Shi, Soojin V. Yi   +5 more
doaj   +1 more source

Neural Networks, Cell Genome and Interactome Nonlinear Dynamic Models [PDF]

, 2011
Operational logic and bioinformatics models of nonlinear dynamics in complex functional systems such as neural networks, genomes and cell interactomes are proposed.
I. C. Baianu
core   +1 more source

Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling

Nature Communications
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory.
Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao   +13 more
doaj   +1 more source

Psychological Safety Among Interprofessional Pediatric Oncology Teams in Germany: A Nationwide Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events.
Alexandros Rahn, Anna‐Lena Herbach, Christian Bock, Katharina Fleig, Urs Mücke   +4 more
wiley   +1 more source

Comparison of robust tests for genetic association using case-control studies

, 2006
In genetic studies of complex diseases, the underlying mode of inheritance is often not known. Thus, the most powerful test or other optimal procedure for one model, e.g. recessive, may be quite inefficient if another model, e.g.
Freidlin, Boris, Gastwirth, Joseph L., Zheng, Gang   +2 more
core   +1 more source

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Personalized transcriptional network analysis links age-related loss of gene coordination to individual biological aging

Genome Medicine
Background Aging is characterized by the decline in biological functions, accompanied by changes in gene-to-gene transcriptional coordination, which can be estimated by expression coordination in gene transcriptional network.
Hao-Tian Wang, Fu-Hui Xiao, Long Zhao, Qian Su, Tian-Rui Xia, Li-Qin Yang, Si-Yu Ma, Qing-Peng Kong   +7 more
doaj   +1 more source

ATM deficiency drives phenotypic diversity and Purkinje cell degeneration in a macaque model of ataxia-telangiectasia

Cell Reports Medicine
Summary: Ataxia-telangiectasia (A-T) is a hereditary neurodegenerative disorder caused by mutations in the ATM (ataxia-telangiectasia mutated) gene. Although existing rodent models reproduce some of the multi-systemic features of A-T, they notably fail ...
Kaiyu Xu, Ying Zhang, Yongxuan Chen, Xiaojia Zhu, Yu Li, Longbao Lv, Xiechao He, Zhengfei Hu, Yifan Li, Maosen Ye, Dewei Jiang, Zhanlong He, Weihua Jin, Yanyan Li, Xiaomei Yu, Deng-Feng Zhang, Karl Herrup, Ping Zheng, Yong-Gang Yao, Dong-Dong Wu, Jiali Li   +20 more
doaj   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Molecular Neurodegeneration
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation.
Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao   +4 more
doaj   +1 more source