Results 1 to 10 of about 3,504,761 (286)

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety

Bio-Protocol, 2023
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern.
Ngoc Tung Tran, Mikhail Lebedin, Eric Danner, Ralf Kühn, Klaus Rajewsky, Van Trung Chu   +5 more
doaj   +1 more source

Molecular Modeling [PDF]

, 1994
Molecular Modeling: From Virtual Tools to Real Problems Reliability of X-Ray Crystallographic Structures Determining the Solution Conformation of Receptor-Bound Ligands by NMR: A Transferred Nuclear Overhauser Effect Study of the Peptidyl Prolyl Cis-Trans Isomerase Cyclophilin and a Model Substrate Modeling Biologically Relevant Peptides Using Circular
openaire   +1 more source

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

Journal of Translational Medicine, 2023
Background Glioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival rate of less than 6% with traditional surgery and chemoradiotherapy, which calls for novel immunotherapies
Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao   +6 more
doaj   +1 more source

The lees extracts of Philippine rice wine (Tapuy) protect transgenic Caenorhabditis elegans from glyphosate-induced neurotoxicity

Food Production, Processing and Nutrition
Tapuy is an indigenous rice wine traditionally prepared during rituals and ceremonies in the northern regions of the Philippines. Its fermentation by-product, the Tapuy lees, is nutrient-dense but is underutilized for human consumption.
Junelle Rey C. Bacong, Mark Joseph R. Remucal, Paul Mark B. Medina   +2 more
doaj   +1 more source

Ultrasensitive gene regulation by positive feedback loops in nucleosome modification

Molecular Systems Biology, 2008
Eukaryotic transcription involves the synergistic interaction of many different proteins. However, the question remains how eukaryotic promoters achieve ultrasensitive or threshold responses to changes in the concentration or activity of a single ...
Kim Sneppen, Mille A Micheelsen, Ian B Dodd   +2 more
doaj   +1 more source

Neurotoxic and neuromotor effects of cyanate, an oxidative byproduct of cyanide from linamarin in cassava: A systematic review

NAJFNR
Background Linamarin-induced neurotoxicity manifests as either polyneuropathy, ataxia, and sensorineural deafness or as isolated symmetric spastic paraparesis of bilateral limbs, which are frequently observed in populations subsisting on a monotonous ...
Rafael Vincent Manalo, Antonio Lorenzo Ong, Paul Mark Medina   +2 more
doaj   +1 more source

ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis

Molecular Medicine, 2020
Background Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis.
Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li, Zhi-Yong Luo   +9 more
doaj   +1 more source

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Molecular Neurodegeneration
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation.
Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao   +4 more
doaj   +1 more source

Towards a Cure for Diamond–Blackfan Anemia: Views on Gene Therapy

Cells
Diamond–Blackfan anemia (DBA) is a rare genetic disorder affecting the bone marrow’s ability to produce red blood cells, leading to severe anemia and various physical abnormalities.
Matilde Vale, Jan Prochazka, Radislav Sedlacek   +2 more
doaj   +1 more source